SynthesisInternational ophthalmology2021
DSAEK or DMEK for failed penetrating keratoplasty: a systematic review and single-arm meta-analysis.
Synthesis in International ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- DMEK, DSAEK, and repeat PKP for endothelial failure after PKP: systematic review and meta-analysis with a graphical synthesis of clinical decision factors.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Prescription patterns in DMEK: European survey.Journal of cataract and refractive surgery · 2025Article
- Non-Descemet Stripping Automated Endothelial Keratoplasty (nDSAEK) for Late Endothelial Failure After Mushroom Keratoplasty: A Retrospective Analysis of Visual and Anatomical Outcomes.Journal of clinical medicine · 2025Article
- Intraoperative Optical Coherence Tomography (OCT)-Guided Femtosecond Laser-Assisted Descemet Membrane Endothelial Keratoplasty (iFAD).Bioengineering (Basel, Switzerland) · 2024Article
- The progress and future of corneal endothelial transplantation.Japanese journal of ophthalmology · 2024Review
- Descemet Membrane Endothelial Keratoplasty after failed penetrating keratoplasty- case series and review of the literature.BMC ophthalmology · 2024Review
- Late central graft detachment due to double endothelial layer after repeat Descemet membrane endothelial keratoplasty.American journal of ophthalmology case reports · 2023Article
- Scheimpflug Corneal Densitometry Patterns at the Graft-Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study.Journal of clinical medicine · 2023Article
- Prospective Safety Evaluation of the Femtosecond Laser-Assisted Keratomileusis Procedure in Correcting Residual Ametropia in Patients After Deep Anterior Lamellar Keratoplasty.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Risk Factors for Descemet Membrane Endothelial Keratoplasty Rejection: Current Perspectives- Systematic Review.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
- Descemet's membrane endothelial keratoplasty for primary graft failure after penetrating keratoplasty.Arquivos brasileiros de oftalmologia · 2022Article
- Evolution of corneal transplantation techniques and their indications in a French corneal transplant unit in 2000-2020.PloS one · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo review the published literature on indications and outcomes of DSAEK/DSEK and DMEK for the treatment of failed penetrating keratoplasty.
designThis is a systematic review and single-arm meta-analysis.
methodsLiterature searches were conducted in PubMed, Embase, Web of Science, and the Cochrane Database of Systematic Reviews. Prospective and retrospective studies reporting DSAEK/DSEK or DMEK after failed penetrating keratoplasty were included. Primary outcome measures are graft survival and detachment rates, as well as postoperative visual outcomes.
resultsA total of 25 studies with 970 patients/989 eyes were included, comprising 735 patients with 746 eyes which underwent DSAEK/DSEK surgery and 235 patients with 243 eyes which underwent DMEK surgery, all of them following a previously failed PK. There were no randomized controlled studies. In all of the DSAEK-PK studies, the graft failure rate was 18% (10%, 26%), the detachment rate was 15% (9%, 22%) and the rejection rate was 7% (3%, 12%) by the time of the last follow-up. And in all of the DMEK-PK studies, the graft failure rate was 14% (4%, 27%), the detachment rate was 42% (28%, 56%) and the rejection rate was 7% (2%, 16%). The mean visual acuity of the DSAEK-PK and DMEK-PK groups is 0.65 ± 0.18 and 0.43 ± 0.23 logMAR, respectively, at 6 months postoperatively.
conclusionsEndothelial keratoplasty for treatment of failed penetrating keratoplasty led to improved vision and graft clarity in most recipients. Though graft survival rates and rejection rates were comparable between the two groups, the DMEK-PK group showed better visual outcomes with higher detachment rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.