Evidence map›Paper›PMID 34117926›Full record

ArticleJournal of materials science. Materials in medicine2021

Microfibrillated cellulose films containing chitosan and tannic acid for wound healing applications.

Meysam Aliabadi, Bor Shin Chee, Mailson Matos, Yvonne J Cortese, Michael J D Nugent, Tielidy A M de Lima, Washington L E Magalhães, Gabriel Goetten de Lima, Mohammadreza Dehghani Firouzabadi

Open access · goldAbstract read
In one paragraph

Article in Journal of materials science. Materials in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Meysam AliabadiDepartment of Paper sciences and engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.
Bor Shin CheeMaterials Research Institute, Athlone Institute of Technology, Athlone, Ireland.
Mailson MatosPrograma de Pós-Graduação em Engenharia e Ciência dos Materiais - PIPE, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
Yvonne J CorteseMaterials Research Institute, Athlone Institute of Technology, Athlone, Ireland.
Michael J D NugentMaterials Research Institute, Athlone Institute of Technology, Athlone, Ireland.
Tielidy A M de LimaMaterials Research Institute, Athlone Institute of Technology, Athlone, Ireland.
Washington L E MagalhãesEmbrapa Florestas, Colombo, Brazil.
Gabriel Goetten de LimaMaterials Research Institute, Athlone Institute of Technology, Athlone, Ireland. ggoetten@research.ait.ie.ORCID http://orcid.org/0000-0002-6161-4626
Mohammadreza Dehghani FirouzabadiDepartment of Paper sciences and engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran. m_r_dehghani@mail.ru.
Athlone Institute of Technology · IEGorgan University of Agricultural Sciences and Natural Resources · IRBrazilian Agricultural Research Corporation · BRUniversidade Federal do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effectiveness of tannic acid as antimicrobial and wound healing for burns have been shown for a century; however, uncontrolled target dosage may result in undesirable side-effects. Remarkably, tannic acid polyphenols compounds crosslinked with polymeric materials produce a strong composite containing the beneficial properties of this tannin. However, investigation of the crosslink structure and its antibacterial and regenerative properties are still unknown when using nanocellulose by mechanical defibrillation; additionally, due to the potential crosslink structure with chitosan, its structure can be complex. Therefore, this work uses bleach kraft nanocellulose in order to investigate the effect on the physical and regenerative properties when incorporated with chitosan and tannic acid. This film results in increased rigidity with a lamellar structure when incorporated with tannic acid due to its strong hydrogen bonding. The release of tannic acid varied depending on the structure it was synthesised with, whereas with chitosan it presented good release model compared to pure cellulose. In addition, exhibiting similar thermal stability as pure cellulose films with antibacterial properties tested against S. aureus and E. coli with good metabolic cellular viability while also inhibiting NF-κB activity, a characteristic of tannic acid.

Indexed as

Wound HealingAnti-Bacterial AgentsAnti-Infective AgentsAntioxidantsBandagesBenzothiazolesBiphenyl CompoundsCell LineCell SurvivalCelluloseChitosanCross-Linking ReagentsDrug LiberationEscherichia coliGelsHumans1,1-diphenyl-2-picrylhydrazyl2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acidAnti-Bacterial AgentsAnti-Infective AgentsAntioxidantsBenzothiazolesBiphenyl CompoundsCelluloseChitosanCross-Linking ReagentsGelsNF-kappa BPicratesPolyphenolsSulfonic AcidsTannins

Identifiers

PMID34117926
PMCPMC8197706
OpenAlexW3170353203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.