ArticleGlia2021
Features of hippocampal astrocytic domains and their spatial relation to excitatory and inhibitory neurons.
Article in Glia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Astrocytic mGluR5 Regulation of Synaptic Transmission is Activity-Dependent in Adult Rats.Glia · 2026Article
- Calcium Dynamics in Astrocyte-Neuron Communication from Intracellular to Extracellular Signaling.Cells · 2025Review
- Live STED imaging of functional neuroanatomy.Nature protocols · 2025Review
- Emerging roles of astrocytes in hippocampal circuitry and behavior.Frontiers in cellular neuroscience · 2025Review
- Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes.Nature communications · 2024Article
- Centripetal integration of past events in hippocampal astrocytes regulated by locus coeruleus.Nature neuroscience · 2024Article
- Astrocytes control recent and remote memory strength by affecting the recruitment of the CA1→ACC projection to engrams.Cell reports · 2024Article
- Regional Microglial Response in Entorhino-Hippocampal Slice Cultures to Schaffer Collateral Lesion and Metalloproteinases Modulation.International journal of molecular sciences · 2024Article
- Computational modeling of the relationship between morphological heterogeneity and functional responses in mouse hippocampal astrocytes.Frontiers in cellular neuroscience · 2024Article
- Engram stability and maturation during systems consolidation.Current biology : CB · 2023Article
- The developmental profile of visual cortex astrocytes.iScience · 2023Article
- Calcium signaling in astrocytes and gliotransmitter release.Frontiers in synaptic neuroscience · 2023Review
- Multiple forms of working memory emerge from synapse-astrocyte interactions in a neuron-glia network model.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- CellDART: cell type inference by domain adaptation of single-cell and spatial transcriptomic data.Nucleic acids research · 2022Article
- Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization.Pharmacology & therapeutics · 2022Review
- Fluorescent transgenic mouse models for whole-brain imaging in health and disease.Frontiers in molecular neuroscience · 2022Review
- Digital Reconstruction of the Neuro-Glia-Vascular Architecture.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The mounting evidence for the involvement of astrocytes in neuronal circuits function and behavior stands in stark contrast to the lack of detailed anatomical description of these cells and the neurons in their domains. To fill this void, we imaged >30,000 astrocytes in hippocampi made transparent by CLARITY, and determined the elaborate structure, distribution, and neuronal content of astrocytic domains. First, we characterized the spatial distribution of >19,000 astrocytes across CA1 lamina, and analyzed the morphology of thousands of reconstructed domains. We then determined the excitatory somatic content of CA1 astrocytes, and measured the distance between inhibitory neuronal somata to the nearest astrocyte soma. We find that on average, there are almost 14 pyramidal neurons per domain in the CA1, increasing toward the pyramidal layer midline, compared to only five excitatory neurons per domain in the amygdala. Finally, we discovered that somatostatin neurons are found in close proximity to astrocytes, compared to parvalbumin and VIP inhibitory neurons. This work provides a comprehensive large-scale quantitative foundation for studying neuron-astrocyte interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.