Evidence map›Paper›PMID 34117597›Full record

ArticleTransgenic research2021

Severe liver disease resembling PSC in mice with K5-Cre mediated deletion of Krüppel-like factor 5 (Klf5).

Åsa Bergström, Marco Gerling, Noémi Van Hul, Carlos Fernández Moro, Björn Rozell, Rune Toftgård, Inderpreet Sur

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transgenic research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Åsa BergströmDepartment of Biosciences and Nutrition, Karolinska Institutet, 141 83, Huddinge, Sweden.
Marco GerlingDepartment of Biosciences and Nutrition, Karolinska Institutet, 141 83, Huddinge, Sweden.
Noémi Van HulDepartment of Cell and Molecular Biology, Karolinska Institutet, 171 77, Stockholm, Sweden.
Carlos Fernández MoroDepartment Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, 141 86, Stockholm, Sweden.
Björn RozellDepartment of Laboratory Medicine, Karolinska Institutet, 141 52, Huddinge, Sweden.
Rune ToftgårdDepartment of Biosciences and Nutrition, Karolinska Institutet, 141 83, Huddinge, Sweden.
Inderpreet SurDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden. inderpreet.sur@ki.se.ORCID 0000-0001-5787-1040
Karolinska Institutet · SEKarolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic cholestatic liver diseases including primary sclerosing cholangitis (PSC) present a complex spectrum with regards to the cause, age of manifestation and histopathological features. Current treatment options are severely limited primarily due to a paucity of model systems mirroring the disease. Here, we describe the Keratin 5 (K5)-Cre; Klf5

Indexed as

Cholangitis, SclerosingLiver DiseasesAnimalsIntegrasesKeratin-5Kruppel-Like Transcription FactorsLiverMiceCre recombinaseIntegrasesKeratin-5Kruppel-Like Transcription FactorsAnimal modelKnock-out miceLiverPSCTranscription factor

Identifiers

PMID34117597
PMCPMC8478727
OpenAlexW3169144448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.