Evidence map›Paper›PMID 34117571›Full record

ArticleInflammopharmacology2021

Biosynthesis of gold nanoparticles for the treatment of osteoarthritis alone or in combination with Diacerein

Manal A Abdel-Aziz, Helmy M S Ahmed, Aziza A El-Nekeety, Hafiza A Sharaf, Sekena H Abdel-Aziem, Mosaad A Abdel-Wahhab

Abstract read
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In one paragraph

Article in Inflammopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. ROS-Sensitive MgOSiOInternational journal of nanomedicine · 2025
    Article
  3. Article
  4. Animal Models of Osteoarthritis: Updated Models and Outcome Measures 2016-2023.Regenerative engineering and translational medicine · 2024
    Article
  5. Functional Nanomaterials for the Treatment of Osteoarthritis.International journal of nanomedicine · 2024
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Manal A Abdel-AzizDepartment of Toxicology and Pharmacology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Helmy M S AhmedDepartment of Toxicology and Pharmacology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. helmy-moawad@yahoo.com.
Aziza A El-NekeetyDepartment of Food Toxicology and Contaminants, National Research Center, Dokki, Cairo, Egypt.
Hafiza A SharafDepartment of Pathology, National Research Center, Dokki, Cairo, Egypt.
Sekena H Abdel-AziemDepartment of Cell Biology, National Research Center, Dokki, Cairo, Egypt.
Mosaad A Abdel-WahhabDepartment of Food Toxicology and Contaminants, National Research Center, Dokki, Cairo, Egypt. ma.abdelwahab@nrc.Sc.eg.ORCID http://orcid.org/0000-0002-7174-3341
National Research Centre · EGCairo University · EG

Funding

National Research Centre 12050305
6 · The paper itself

Abstract

Gold (Au) compounds were used as an effective therapeutic agent for various inflammatory diseases; however, the use of Au compounds becomes limited because of its association with several side effects. Hence, gold nanoparticles (AuNPs) were developed as a new option for the medical proposes. However, the safety evaluation of gold nanoparticles (AuNPs) in osteoarthritis (OA) treatment remains vague. This study aimed to biosynthesize, characterize and evaluate the therapeutic effects of biosynthesized AuNPs and/or Diacerein

Indexed as

ChenopodiumAnimalsAnthraquinonesAnti-Inflammatory AgentsDisease Models, AnimalDrug Therapy, CombinationFemaleGoldIodoacetic AcidMetal NanoparticlesOsteoarthritisPlant ExtractsRatsRats, Sprague-DawleyTreatment OutcomeAnthraquinonesAnti-Inflammatory AgentsdiacereinGoldIodoacetic AcidPlant ExtractsDNA fragmentationInflammatory cytokinesNano-medicineNanotechnologyOsteoarthritis, gold nanoparticles, diacereinOxidative stress

Identifiers

PMID34117571
OpenAlexW3170777362

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.