ArticleCommunications biology2021
Inhibitory neurons in the superior colliculus mediate selection of spatially-directed movements.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Somatosensory cortex shapes perceptual decision bias via the superior colliculus.Research square · 2026Article
- Evolutionarily old brainstem neurons are required for the control of selective spatial attention.Nature communications · 2026Article
- Correlates of head-fixed directional forelimb movements in mouse superior colliculus and substantia nigra pars reticulata.Neuroscience · 2026Article
- Neuronal Features of Visual Attention in the Mouse Superior Colliculus Depend on Learned Behavioral Relevance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Functional specialisation of multisensory temporal integration in the mouse superior colliculus.Nature communications · 2025Article
- Altered GABAergic signaling and chloride homeostasis in eye movement circuits during late neurodevelopment: implications for Alzheimer's disease therapy.Frontiers in pharmacology · 2025Review
- Genetically defined neuron types underlying visuomotor transformation in the superior colliculus.Nature reviews. Neuroscience · 2024Review
- Stimulus-dependent differences in cortical versus subcortical contributions to visual detection in mice.Current biology : CB · 2024Article
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- Pathways from the Superior Colliculus to the Basal Ganglia.Current neuropharmacology · 2024Review
- Superior colliculus bidirectionally modulates choice activity in frontal cortex.Nature communications · 2023Article
- Neural mechanisms for the localization of unexpected external motion.Nature communications · 2023Article
- Retinal input integration in excitatory and inhibitory neurons in the mouse superior colliculus in vivo.eLife · 2023Article
- Superior colliculus cell types bidirectionally modulate choice activity in frontal cortex.bioRxiv : the preprint server for biology · 2023Article
- Neuronal density and expression of calcium-binding proteins across the layers of the superior colliculus in the common marmoset (Callithrix jacchus).The Journal of comparative neurology · 2022Article
- The Superior Colliculus: Cell Types, Connectivity, and Behavior.Neuroscience bulletin · 2022Review
- A Midbrain Inspired Recurrent Neural Network Model for Robust Change Detection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Optogenetic activation of the inhibitory nigro-collicular circuit evokes contralateral orienting movements in mice.Cell reports · 2022Article
- Neuronal modulation in the mouse superior colliculus during covert visual selective attention.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Decision making is a cognitive process that mediates behaviors critical for survival. Choosing spatial targets is an experimentally-tractable form of decision making that depends on the midbrain superior colliculus (SC). While physiological and computational studies have uncovered the functional topographic organization of the SC, the role of specific SC cell types in spatial choice is unknown. Here, we leveraged behavior, optogenetics, neural recordings and modeling to directly examine the contribution of GABAergic SC neurons to the selection of opposing spatial targets. Although GABAergic SC neurons comprise a heterogeneous population with local and long-range projections, our results demonstrate that GABAergic SC neurons do not locally suppress premotor output, suggesting that functional long-range inhibition instead plays a dominant role in spatial choice. An attractor model requiring only intrinsic SC circuitry was sufficient to account for our experimental observations. Overall, our study elucidates the role of GABAergic SC neurons in spatial choice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.