ArticleScientific reports2021
Detecting functional connectivity disruptions in a translational pediatric traumatic brain injury porcine model using resting-state and task-based fMRI.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Cell-free DNA methylation profiling reveals injury types and severities in swine rotational and contusional models of traumatic brain injury.Acta neuropathologica communications · 2026Article
- Comparative Mapping of Functional and Structural Homologies in the Pig and Human Brain.bioRxiv : the preprint server for biology · 2026Article
- From artery to memory: a comparative review of vascular cognitive impairment surgical models.Frontiers in aging neuroscience · 2026Review
- Advances and challenges in experimental models of posttraumatic epilepsy for therapeutic interventions.Pharmacological reviews · 2025Review
- A novel integration of brain structural and functional connectivity for identifying traumatic brain injury induced perturbations.Journal of neuroscience methods · 2025Article
- fMRI-based data-driven brain parcellation using independent component analysis.Journal of neuroscience methods · 2025Article
- Article
- White Matter Integrity and Motor Function Disruption Due to Traumatic Brain Injury in Piglets: Impacts on Motor-Related Brain Fibers.Brain sciences · 2024Article
- Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Evaluation of Brain Function Recovery After Traumatic Brain Injury Treatment in a Porcine Model by Cross-Group Temporal-Spatial Correlation Analysis.Neurotrauma reports · 2024Article
- The Pig as a Translational Animal Model for Biobehavioral and Neurotrauma Research.Biomedicines · 2023Review
- Changes in a sensorimotor network, occipital network, and psychomotor speed within three months after focal surgical injury in pediatric patients with intracranial space-occupying lesions.BMC pediatrics · 2022Article
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Authors and funding
8 authors.
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Abstract
Functional magnetic resonance imaging (fMRI) has significant potential to evaluate changes in brain network activity after traumatic brain injury (TBI) and enable early prognosis of potential functional (e.g., motor, cognitive, behavior) deficits. In this study, resting-state and task-based fMRI (rs- and tb-fMRI) were utilized to examine network changes in a pediatric porcine TBI model that has increased predictive potential in the development of novel therapies. rs- and tb-fMRI were performed one day post-TBI in piglets. Activation maps were generated using group independent component analysis (ICA) and sparse dictionary learning (sDL). Activation maps were compared to pig reference functional connectivity atlases and evaluated using Pearson spatial correlation coefficients and mean ratios. Nonparametric permutation analyses were used to determine significantly different activation areas between the TBI and healthy control groups. Significantly lower Pearson values and mean ratios were observed in the visual, executive control, and sensorimotor networks for TBI piglets compared to controls. Significant differences were also observed within several specific individual anatomical structures within each network. In conclusion, both rs- and tb-fMRI demonstrate the ability to detect functional connectivity disruptions in a translational TBI piglet model, and these disruptions can be traced to specific affected anatomical structures.
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