ArticleScientific reports2021
Etiology, incidence, and outcomes of patient-ventilator asynchrony in critically-ill patients undergoing invasive mechanical ventilation.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07656259 (COMPARE-VENT Feasibility Pilot Study), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
COMPARE-VENT Feasibility Pilot Study: A Pragmatic Cluster Randomized Crossover Trial for Ventilation Strategies and Hemodynamic Impact in Critically Ill Patients With Cardiovascular Disease
Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- Mechanical power guided lung protective ventilation in acute respiratory failure using the VentCoach approach.Scientific reports · 2026Trial
- Effect of a patient-ventilator asynchrony (PVA) management protocol on treatment outcomes in ICU patients: a randomized controlled trial.BMC research notes · 2025Trial
- Physiology-guided mechanical ventilation: Monitoring, proportional assist, and bounded automation.World journal of critical care medicine · 2026Review
- Challenges and strategies for the identification and correction of patient-ventilator asynchronies in daily practice: a scoping review.Acute and critical care · 2026Article
- Deep learning for time-series segmentation of mechanical ventilator waveforms.Scientific reports · 2026Article
- Consensus on identifying and ranking ventilator asynchronies in invasively ventilated ICU patients: a modified Delphi study (SYNAPsE).Intensive care medicine · 2026Article
- STOP algorithm for bedside mechanical ventilation: Standardized, evidence-based management of critically ill patients.Biomolecules & biomedicine · 2026Article
- Asynchrony index modified: An improved tool for estimating the quality of patient-ventilator interaction.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2026Article
- Ventilatory asynchronies induced by routine clinical practices in the intensive care unit: A systematic observation combined with a scoping review.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2026Article
- Preferences for mechanical ventilation modes among intensivists in Türkiye: a nationwide point-prevalence study.Turkish journal of medical sciences · 2026Article
- Methodological development of the remote ventilate view platform for real-time monitoring of patient-ventilator asynchrony and respiratory parameters in severe pneumonia patients.Journal of intensive medicine · 2025Article
- Ability to identify patient-ventilator asynchronies in intensive care unit professionals: A multicenter cross-sectional analytical study.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Article
- Let's get in sync: current standing and future of AI-based detection of patient-ventilator asynchrony.Intensive care medicine experimental · 2025Review
- Evaluation of health care providers' ability to identify patient-ventilator triggering asynchrony in intensive care unit: a translational observational study in China.BMC medical education · 2025Observational
- Optimizing Mechanical Ventilation: A Clinical and Practical Bedside Method for the Identification and Management of Patient-Ventilator Asynchronies in Critical Care.Journal of clinical medicine · 2025Review
- Optimizing Mechanical Ventilation Strategies in ARDS: The Role of Driving Pressure and Low Tidal Volume Ventilation.Critical care research and practice · 2025Review
- Induction of subject-ventilator asynchrony by variation of respiratory parameters in a lung injury model in pigs.Respiratory research · 2024Article
- Article
- Survey of Ventilator Waveform Interpretation Among ICU Professionals.Respiratory care · 2024Article
- Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patient-ventilator asynchrony (PVA) is commonly encountered during mechanical ventilation of critically ill patients. Estimates of PVA incidence vary widely. Type, risk factors, and consequences of PVA remain unclear. We aimed to measure the incidence and identify types of PVA, characterize risk factors for development, and explore the relationship between PVA and outcome among critically ill, mechanically ventilated adult patients admitted to medical, surgical, and medical-surgical intensive care units in a large academic institution staffed with varying provider training background. A single center, retrospective cohort study of all adult critically ill patients undergoing invasive mechanical ventilation for ≥ 12 h. A total of 676 patients who underwent 696 episodes of mechanical ventilation were included. Overall PVA occurred in 170 (24%) episodes. Double triggering 92(13%) was most common, followed by flow starvation 73(10%). A history of smoking, and pneumonia, sepsis, or ARDS were risk factors for overall PVA and double triggering (all P < 0.05). Compared with volume targeted ventilation, pressure targeted ventilation decreased the occurrence of events (all P < 0.01). During volume controlled synchronized intermittent mandatory ventilation and pressure targeted ventilation, ventilator settings were associated with the incidence of overall PVA. The number of overall PVA, as well as double triggering and flow starvation specifically, were associated with worse outcomes and fewer hospital-free days (all P < 0.01). Double triggering and flow starvation are the most common PVA among critically ill, mechanically ventilated patients. Overall incidence as well as double triggering and flow starvation PVA specifically, portend worse outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.