ArticleNature communications2021
Overexpression of human BAG3
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function.Circulation research · 2026Article
- The R120G knock-in mutation in αB-crystallin is insufficient to induce cardiomyopathy in mice.American journal of physiology. Heart and circulatory physiology · 2026Article
- Fractionated proteomics identifies a protein network mitigating resistance exercise-induced damage in human skeletal muscle.Nature communications · 2026Article
- RNA-Based Therapies for Treating Monogenic Cardiomyopathies.The Canadian journal of cardiology · 2026Review
- Blockage of autophagy causes severe skeletal muscle disruption in a mouse model for myofibrillar myopathy 6.Nature communications · 2026Article
- Cyclic stretch induces autophagy-mediated focal adhesion remodeling and activates mitochondria.Life science alliance · 2026Article
- Heart Failure in the Molecular Era: Redefining Our Understanding of Disease Mechanisms and Perspectives.Biomedicines · 2026Review
- Disease spectrum and long-term prognosis of patients with BAG3-associated neuromuscular diseases in Europe.Brain : a journal of neurology · 2025Article
- Phosphorylation of CRYAB induces a condensatopathy to worsen post-myocardial infarction left ventricular remodeling.The Journal of clinical investigation · 2025Article
- Identification of phosphatases that dephosphorylate the co-chaperone BAG3.Life science alliance · 2025Article
- Integrative proteomic and metabolomic elucidation of cardiomyopathy with in vivo and in vitro models and clinical samples.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Review
- BAG3 promotes proliferation and migration of arterial smooth muscle cells by regulating STAT3 phosphorylation in diabetic vascular remodeling.Cardiovascular diabetology · 2024Article
- Dysregulated Autophagy and Sarcomere Dysfunction in Patients With Heart Failure With Co-Occurrence of P63A and P380SJournal of the American Heart Association · 2023Article
- HSPB8 frameshift mutant aggregates weaken chaperone-assisted selective autophagy in neuromyopathies.Autophagy · 2023Article
- Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart.JACC. Basic to translational science · 2023Article
- Transcriptome studies of inherited dilated cardiomyopathies.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Review
- Skeletal Muscle-SpecificInternational journal of molecular sciences · 2023Article
- BAG3: Nature's Quintessential Multi-Functional Protein Functions as a Ubiquitous Intra-Cellular Glue.Cells · 2023Review
- Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease.Cell death & disease · 2022Review
- Genetic Insights into Primary Restrictive Cardiomyopathy.Journal of clinical medicine · 2022Review
Corrections and comments
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Authors and funding
22 authors at 7 institutions in 3 countries.
Kenichi Kimura *Institute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0002-0363-8865
Astrid Ooms *Institute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Bonn, Germany.
Kathrin Graf-Riesen *Institute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Bonn, Germany.
Maithreyan KuppusamyCentral Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Jülich, Germany.ORCID 0000-0001-6866-0417
Andreas UngerInstitute of Physiology II, University of Münster, Münster, Germany.
Julia SchuldDepartment of Molecular Cell Biology, Institute for Cell Biology, University of Bonn, Bonn, Germany.
Jan DaerrDepartment of Molecular Cell Biology, Institute for Cell Biology, University of Bonn, Bonn, Germany.
Achim LotherInstitute of Experimental and Clinical Pharmacology and Toxicology, Division II, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Caroline GeisenInstitute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Bonn, Germany.
Lutz HeinInstitute of Experimental and Clinical Pharmacology and Toxicology, Division II, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0003-1297-0007
Satoru TakahashiDepartment of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.ORCID 0000-0002-8540-7760
Guang LiStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-8546-2364
Wilhelm RöllDepartment of Cardiac Surgery, University of Bonn, Bonn, Germany.
Wilhelm BlochGerman Sport University Cologne, Department of Molecular and Cellular Sport Medicine, Cologne, Germany.
Peter F M van der VenDepartment of Molecular Cell Biology, Institute for Cell Biology, University of Bonn, Bonn, Germany.ORCID 0000-0002-9750-8913
Wolfgang A LinkeInstitute of Physiology II, University of Münster, Münster, Germany.ORCID 0000-0003-0801-3773
Sean M WuStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-0000-3821
Pitter F HuesgenCentral Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Jülich, Germany.ORCID 0000-0002-0335-2242
Jörg HöhfeldDepartment of Molecular Cell Biology, Institute for Cell Biology, University of Bonn, Bonn, Germany.
Dieter O FürstDepartment of Molecular Cell Biology, Institute for Cell Biology, University of Bonn, Bonn, Germany.
Bernd K FleischmannInstitute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Bonn, Germany. bernd.fleischmann@uni-bonn.de.ORCID 0000-0002-9202-8363
Michael HesseInstitute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Bonn, Germany. mhesse1@uni-bonn.de.ORCID 0000-0002-7518-0224
University of Bonn · DECardiovascular Institute of the South · USForschungszentrum Jülich · DEUniversity of Freiburg · DEUniversity of Münster · DEGerman Sport University Cologne · DEUniversity of Tsukuba · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
An amino acid exchange (P209L) in the HSPB8 binding site of the human co-chaperone BAG3 gives rise to severe childhood cardiomyopathy. To phenocopy the disease in mice and gain insight into its mechanisms, we generated humanized transgenic mouse models. Expression of human BAG3
Indexed as
Adaptor Proteins, Signal TransducingAnimalsApoptosis Regulatory ProteinsAutophagyBinding SitesCardiomyopathiesCardiomyopathy, RestrictiveChildDisease Models, AnimalGene Expression RegulationGenetic TherapyHeartHeat-Shock ProteinsHumansMiceMice, TransgenicAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsBAG3 protein, humanBag3 protein, mouseHeat-Shock ProteinsHSPB8 protein, humanMolecular Chaperones
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.