Evidence map›Paper›PMID 34117124›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Starvation induces shrinkage of the bacterial cytoplasm.

Handuo Shi, Corey S Westfall, Jesse Kao, Pascal D Odermatt, Sarah E Anderson, Spencer Cesar, Montana Sievert, Jeremy Moore, Carlos G Gonzalez, Lichao Zhang and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Pooled it
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  6. Glycerol-Driven Energy and Proteostasis Underpin Antibiotic Tolerance inbioRxiv : the preprint server for biology · 2026
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  20. Macromolecular Crowding in Cell Stress and Death.Sub-cellular biochemistry · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Handuo ShiDepartment of Bioengineering, Stanford University, Stanford, CA 94305.ORCID 0000-0002-1688-6905
Corey S WestfallDepartment of Biology, Washington University in St. Louis, St. Louis, MO 63130.
Jesse KaoDepartment of Biology, Washington University in St. Louis, St. Louis, MO 63130.
Pascal D OdermattDepartment of Bioengineering, Stanford University, Stanford, CA 94305.
Sarah E AndersonDepartment of Biology, Washington University in St. Louis, St. Louis, MO 63130.ORCID 0000-0003-2064-8165
Spencer CesarDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305.
Montana SievertDepartment of Biology, Washington University in St. Louis, St. Louis, MO 63130.
Jeremy MooreDepartment of Biology, Washington University in St. Louis, St. Louis, MO 63130.ORCID 0000-0001-7593-2273
Carlos G GonzalezDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305.
Lichao ZhangChan Zuckerberg Biohub, San Francisco, CA 94158.
Joshua E EliasChan Zuckerberg Biohub, San Francisco, CA 94158.ORCID 0000-0002-8063-3259
Fred ChangDepartment of Cell and Tissue Biology, University of California, San Francisco, CA 94143.ORCID 0000-0002-8907-3286
Kerwyn Casey HuangDepartment of Bioengineering, Stanford University, Stanford, CA 94305; kchuang@stanford.edu plevin@wustl.edu.ORCID 0000-0002-8043-8138
Petra Anne LevinDepartment of Biology, Washington University in St. Louis, St. Louis, MO 63130; kchuang@stanford.edu plevin@wustl.edu.ORCID 0000-0003-2071-0547
Washington University in St. Louis · USChan Zuckerberg Initiative (United States) · USStanford University · USUniversity of California, San Francisco · US

Funding

ASSEMBLY AND PLACEMENT OF THE CELL DIVISION RINGR01GM056836 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHANG, FRED · 1998 to 2018
$7.4M
HOMEOSTATIC CONTROL OF BACTERIAL GROWTH AND CELL DIVISIONR35GM127331 · NIGMS · WASHINGTON UNIVERSITY · PI Petra Anne Levin · 2018 to 2026
$4.3M
NIGMS NIH HHS R01 GM056836NIGMS NIH HHS R35 GM127331
6 · The paper itself

Abstract

Environmental fluctuations are a common challenge for single-celled organisms; enteric bacteria such as

Indexed as

CarbonCytoplasmDNA ReplicationDown-RegulationEscherichia coliEscherichia coli ProteinsIon ChannelsMechanotransduction, CellularNitrogenPhosphorusCarbonEscherichia coli ProteinsIon ChannelsNitrogenPhosphoruscytoplasmic densitymicrobial stress responseperiplasmstarvationstationary phase

Identifiers

PMID34117124
PMCPMC8214708
OpenAlexW3165968861

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.