ArticleScience immunology2021
Assembly of a spatial circuit of T-bet-expressing T and B lymphocytes is required for antiviral humoral immunity.
Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- B cells drive CD4 T cell immunosenescence and age-associated health decline.Science immunology · 2026Article
- Young children have limited mucosal immunity when stimulated with an influenza vaccine in tonsil organoids.Research square · 2025Article
- CD11c+ Tbet+ B cells constrain obesity- and vaccination-induced germinal center B cells and T helper cells.bioRxiv : the preprint server for biology · 2025Article
- Article
- T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses.The EMBO journal · 2025Article
- Activation of CXCR3Journal of virology · 2025Article
- T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis.Cell reports. Medicine · 2025Article
- T cell-derived IFN-γ Suppresses T Follicular Helper Cell Differentiation and Antibody Responses.bioRxiv : the preprint server for biology · 2025Article
- Follicular helper T cells (Tfh): heterogeneity in spatial distribution and phenotypic characteristics.Frontiers in immunology · 2025Review
- Help me help you: emerging concepts in T follicular helper cell differentiation, identity, and function.Current opinion in immunology · 2024Review
- Antiviral memory B cells exhibit enhanced innate immune response facilitated by epigenetic memory.Science advances · 2024Article
- T-bet-expressing B cells contribute to the autoreactive plasma cell pool in LynEuropean journal of immunology · 2023Article
- Immune surveillance and humoral immune responses in kidney transplantation - A look back at T follicular helper cells.Frontiers in immunology · 2023Review
- Tfh cells and the germinal center are required for memory B cell formation & humoral immunity after ChAdOx1 nCoV-19 vaccination.Cell reports. Medicine · 2022Article
- Age-associated B cells are long-lasting effectors that impede latent γHV68 reactivation.Scientific reports · 2022Article
- Gammaherpesvirus infection drives age-associated B cells toward pathogenicity in EAE and MS.Science advances · 2022Article
- Human T-bet governs the generation of a distinct subset of CD11cScience immunology · 2022Article
- CXCL11 expressing C57BL/6 mice have intact adaptive immune responses to viral infection.Immunology and cell biology · 2022Article
- Information flow in the spatiotemporal organization of immune responses.Immunological reviews · 2022Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Effective antiviral immunity requires generation of T and B lymphocytes expressing the transcription factor T-bet, a regulator of type 1 inflammatory responses. Using T-bet expression as an endogenous marker for cells participating in a type 1 response, we report coordinated interactions of T-bet-expressing T and B lymphocytes on the basis of their dynamic colocalization at the T cell zone and B follicle boundary (T-B boundary) and germinal centers (GCs) during lung influenza infection. We demonstrate that the assembly of this circuit takes place in distinct anatomical niches within the draining lymph node, guided by CXCR3 that enables positioning of T
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.