Evidence map›Paper›PMID 34117072›Full record

ArticleCold Spring Harbor molecular case studies2021

Deletion of

Ram Singh, Ana S A Cohen, Cathryn Poulton, Tina Duelund Hjortshøj, Moe Akahira-Azuma, Geetu Mendiratta, Wahab A Khan, Dimitar N Azmanov, Karen J Woodward, Maria Kirchhoff and 5 more

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cold Spring Harbor molecular case studies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03025763 (Craniosynostosis Network), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03025763 active not recruitingnot on this map

Craniosynostosis Network

TypeobservationalSponsorIcahn School of Medicine at Mount SinaiRan2015 to 2028Enrolled2,145ConditionsCraniosynostosisArmsCraniosynostosis Network Environmental Survey, 2D/3D Photography, Buccal Swab Cell Sampling, Blood sampling, Skin Biopsy
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Ram Singh *Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Ana S A Cohen *Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Cathryn PoultonGenetic Service of Western Australia, King Edward Memorial Hospital, Perth, Western Australia 6008, Australia.
Tina Duelund HjortshøjDepartment of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark.
Moe Akahira-AzumaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Geetu MendirattaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Wahab A KhanDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Dimitar N AzmanovDepartment of Diagnostic Genomics, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.
Karen J WoodwardDepartment of Diagnostic Genomics, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, Western Australia 6009, Australia.
Maria KirchhoffDepartment of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark.
Lisong ShiDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Lisa EdelmannDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Gareth BaynamWestern Australian Register of Developmental Anomalies and Genetic Services of Western Australia, King Edward Memorial Hospital, Perth, Western Australia 6008, Australia.
Stuart A ScottDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.ORCID 0000-0001-5720-1864
Ethylin Wang JabsDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.ORCID 0000-0001-8983-5466
Sema4 (United States) · USCopenhagen University Hospital · DKIcahn School of Medicine at Mount Sinai · USThe University of Western Australia · AUKing Edward Memorial Hospital · AUThe Kids Research Institute Australia · AU

Funding

Project III: Systems Biology of Bone in Coronal Nonsyndromic CraniosynostosisP01HD078233 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JABS, ETHYLIN WANG · 2014 to 2019
$7.0M
NICHD NIH HHS P01 HD078233
6 · The paper itself

Abstract

The ETS2 repressor factor (ERF) is a transcription factor in the RAS-MEK-ERK signal transduction cascade that regulates cell proliferation and differentiation, and pathogenic sequence variants in the

Indexed as

Gene DeletionAdolescentChildChild, PreschoolDevelopmental DisabilitiesDNA Copy Number VariationsFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenetic TestingHeterozygoteHumansIntellectual DisabilityMaleMembrane ProteinsNeurodevelopmental DisordersATP1A3 protein, humanCIC protein, humanERF protein, humanETS2 protein, humanMEGF8 protein, humanMembrane ProteinsProto-Oncogene Protein c-ets-2Repressor ProteinsSodium-Potassium-Exchanging ATPaseTranscription Factorscongenital strabismuscraniosynostosisglobal developmental delayintellectual disabilitymacrocephaly at birthwidely patent coronal suture

Identifiers

PMID34117072
PMCPMC8208047
OpenAlexW3168184408

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.