Evidence map›Paper›PMID 34117033›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2021

Clinical and Functional Characterization of Atypical

Jonathan M Loree, Yucai Wang, Muddassir A Syed, Alexey V Sorokin, Oluwadara Coker, Joanne Xiu, Benjamin A Weinberg, Ari M Vanderwalde, Anteneh Tesfaye, Victoria M Raymond and 12 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. The atypical KRASMolecular oncology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The Landscape of ctDNA in Appendiceal Adenocarcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. International cancer conference journal · 2024
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 11 institutions in 3 countries.

Jonathan M LoreeBC Cancer, Vancouver, British Columbia, Canada.ORCID 0000-0001-8189-2132
Yucai WangMayo Clinic, Rochester, Minnesota.ORCID 0000-0002-1576-8341
Muddassir A SyedThe University of Texas MD Anderson Cancer Center, Houston, Texas.
Alexey V SorokinThe University of Texas MD Anderson Cancer Center, Houston, Texas.
Oluwadara CokerThe University of Texas MD Anderson Cancer Center, Houston, Texas.
Joanne XiuCaris Life Sciences, Phoenix, Arizona.
Benjamin A WeinbergLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC.ORCID 0000-0002-0408-4817
Ari M VanderwaldeWest Cancer Center, Memphis, Tennessee.ORCID 0000-0002-6842-2563
Anteneh TesfayeKarmanos Cancer Institute, Rochester Hills, Michigan.ORCID 0000-0002-7518-1825
Victoria M RaymondGuardant Health Inc., Redwood City, California.ORCID 0000-0001-5223-0981
Benjamin MironNovellus, Jerusalem, Israel.ORCID 0000-0002-5681-3110
Gabi TarcicNovellus, Jerusalem, Israel.ORCID 0000-0001-7469-0647
Ori ZelichovNovellus, Jerusalem, Israel.
Russell R BroaddusUniversity of North Carolina, Chapel Hill, North Carolina.
Patrick Kwok Shing NgThe University of Texas MD Anderson Cancer Center, Houston, Texas.
Kang Jin JeongOregon Health Sciences University Knight Cancer Institute, Portland, Oregon.
Yiu Huen TsangOregon Health Sciences University Knight Cancer Institute, Portland, Oregon.
Gordon B MillsOregon Health Sciences University Knight Cancer Institute, Portland, Oregon.ORCID 0000-0002-0144-9614
Michael J OvermanThe University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0001-5377-135X
Axel GrotheyWest Cancer Center, Memphis, Tennessee.
John L MarshallCaris Life Sciences, Phoenix, Arizona.ORCID 0000-0002-3449-2344
Scott KopetzThe University of Texas MD Anderson Cancer Center, Houston, Texas. skopetz@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USMarvell (Israel) · ILOregon Health & Science University · USCaris Life Sciences (United States) · USWest Cancer Center · USBC Cancer Agency · CAGeorgetown University · USGuardant (United States) · USMayo Clinic · USThe Barbara Ann Karmanos Cancer Institute · USUniversity of North Carolina at Chapel Hill · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Project 3: Inhibiting Oxidative Phosphorylation in Pancreatic CancerP50CA221707 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KOPETZ, SCOTT, MAITRA, ANIRBAN · 2019 to 2023
$11.0M
Tumor Heterogeneity and Acquired Resistance to EGFR InhibitionR01CA184843 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HAMILTON, STANLEY R., KOPETZ, SCOTT · 2015 to 2019
$3.2M
Translational Genomics and Precision Medicine in Cancer Training ProgramT32CA217789 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Subrata Sen · 2018 to 2026
$2.2M
Therapeutic Strategies for Patients With BRAF Mutant Colorectal CancerR01CA187238 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HONG, DAVID S., KOPETZ, SCOTT · 2014 to 2018
$1.7M
NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA221707NCI NIH HHS R01 CA184843NCI NIH HHS R01 CA187238NCI NIH HHS T32 CA217789
6 · The paper itself

Abstract

purposeMutations in EXPERIMENTAL

designWe reviewed 7 tissue and 1 cell-free DNA cohorts of 9,485 patients to characterize atypical

results

conclusionsWe provide best available evidence to guide treatment when atypical

Indexed as

MutationAgedColorectal NeoplasmsFemaleGTP PhosphohydrolasesHumansMaleMembrane ProteinsMiddle AgedNeoplasm MetastasisProto-Oncogene Proteins p21(ras)GTP PhosphohydrolasesKRAS protein, humanMembrane ProteinsNRAS protein, humanProto-Oncogene Proteins p21(ras)

Identifiers

PMID34117033
PMCPMC8364867
OpenAlexW3167814974

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.