Evidence map›Paper›PMID 34117012›Full record

ReviewBMJ global health2021

Epidemic preparedness: Prenatal Zika virus screening during the next epidemic.

Luxi Qiao, Celina M Turchi Martelli, Amber I Raja, Nuria Sanchez Clemente, Thalia Velho Barreto de Araùjo, Ricardo Arraes de Alencar Ximenes, Demócrito de Barros Miranda-Filho, Anna Ramond, Elizabeth B Brickley

Open access · goldAbstract readReview
In one paragraph

Review in BMJ global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. CD4Vaccines · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Nonhuman Primates in Translational Research.Annual review of animal biosciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Luxi QiaoHealth Equity Action Lab, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Celina M Turchi MartelliInstituto Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, Pernambuco, Brasil.
Amber I RajaHealth Equity Action Lab, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Nuria Sanchez ClementeHealth Equity Action Lab, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Thalia Velho Barreto de AraùjoDepartamento de Medicina Social, Universidade Federal de Pernambuco, Recife, Pernambuco, Brasil.
Ricardo Arraes de Alencar XimenesDepartamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Pernambuco, Brasil.
Demócrito de Barros Miranda-FilhoDepartamento de Medicina Interna, Universidade de Pernambuco, Recife, Pernambuco, Brasil.
Anna RamondHealth Equity Action Lab, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Elizabeth B BrickleyHealth Equity Action Lab, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK elizabeth.brickley@lshtm.ac.uk.ORCID 0000-0003-0280-2288
London School of Hygiene & Tropical Medicine · GBUniversidade Federal de Pernambuco · BRFundação Oswaldo Cruz · BRUniversidade de Pernambuco · BRWashington University in St. Louis · US

Funding

Medical Research Council MC_PC_15088Wellcome Trust 205377/Z/16/Z
6 · The paper itself

Abstract

Zika virus (ZIKV) is a vectorborne infectious agent of global public health significance due to its potential to cause severe teratogenic outcomes. The question of whether health systems should consider adopting screening programmes for ZIKV infections during pregnancy warrants consideration. In this analysis, we apply the Wilson-Jungner framework to appraise the potential utility of a prenatal ZIKV screening programme, outline potential screening strategies within the case-finding pathway, and consider other epidemiological factors that may influence the planning of such a screening programme. Our evaluation of a potential prenatal ZIKV screening programme highlights factors affirming its usefulness, including the importance of Congenital Zika Syndrome as a public health problem and the existence of analogous congenital prenatal screening programmes for STORCH agents (syphilis, toxoplasmosis, others (eg, human immunodeficiency virus, varicella-zoster virus, parvovirus B19), rubella, cytomegalovirus, and herpes simplex virus). However, our assessment also reveals key barriers to implementation, such as the need for more accurate diagnostic tests, effective antiviral treatments, increased social service capacity, and surveillance. Given that the reemergence of ZIKV is likely, we provide a guiding framework for policymakers and public health leaders that can be further elaborated and adapted to different contexts in order to reduce the burden of adverse ZIKV-related birth outcomes during future outbreaks.

Indexed as

EpidemicsVirus DiseasesZika VirusZika Virus InfectionFemaleHumansPregnancyPrenatal DiagnosisArbovirusesChild healthMaternal healthPublic HealthScreeningZika virus

Identifiers

PMID34117012
PMCPMC8202108
OpenAlexW3169540303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.