ArticleFertility and sterility2021
Impact of ambient temperature on ovarian reserve.
Article in Fertility and sterility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- The impacts of climate change on women's reproductive and sexual health: a systematic review.Reproductive health · 2026Pooled it
- The effects of heat stress on the ovary, follicles, and oocytes: a systematic review†.Biology of reproduction · 2025Pooled it
- Co-exposure to high temperature and mono(2-ethylhexyl) phthalate inhibits mouse antral follicle growth and estradiol synthesis: phthalate-heat interactions in the ovary.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- The association between heat waves and pregnancy outcome among women undergoing assisted reproductive technology in Sichuan, China.BMC public health · 2026Article
- Declines in ovarian reserve associated with ambient ozone exposure: mediating role of lipid profile.Lipids in health and disease · 2026Article
- Early-life exposure to ambient temperature and polycystic ovary syndrome: a nationwide cohort study.International journal of epidemiology · 2026Article
- From Systemic Stress to Ovarian Failure: Heat Stress-Induced Infertility in Pigs as a Model for Reproductive Dysfunction.Current issues in molecular biology · 2026Review
- Investigating ovarian effects of perfluorooctanoic acid in postpubertal pigs during thermal neutral and heat stress conditions.Journal of animal science · 2026Article
- Circulating sex hormones, specifically estrogen in females and testosterone in males, are associated with ambient environmental temperature during prolonged physical training.Temperature (Austin, Tex.) · 2026Article
- Enhancing antioxidant capacity via NRF2 pathway activation to mitigate heat stress-induced oxidative damage in bovine granulosa cells, oocytes, and embryos.Frontiers in cell and developmental biology · 2026Article
- Effects of different seasons on the outcome ofFrontiers in reproductive health · 2026Article
- Heat and chemical stressors: Independent and interactive impacts on the pig ovary.The Journal of reproduction and development · 2026Review
- Incidence of different histologic subtype of ovarian cancer in China: a population-based cancer registry study.BMC women's health · 2025Article
- The impact of season, temperature, and direct normal irradiance on IVF pregnancy outcomes: a retrospective cohort study.International journal of biometeorology · 2025Article
- Navigating parenthood in a climate change era: determinants of childbearing intentions in Iran.Scientific reports · 2025Article
- Diverse roles of stress-responsive RNP granules in oogenesis and infertility.Biology of reproduction · 2025Review
- Ambient temperature in relation to ovarian reserve and early outcomes following ovarian stimulation and in vitro fertilization.Environmental research · 2025Article
- High-altitude hypoxia exposure alters follicular metabolome and oocyte developmental potential in women.Archives of gynecology and obstetrics · 2025Article
- Ambient temperature and female infertility prevalence: an ecological study based on the 2019 global burden of disease study.Reproductive biology and endocrinology : RB&E · 2025Article
- The association between season and meteorological factors on clinical outcomes after fresh embryo transfer: a cohort study from Central Plains, China.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo examine the association between ambient temperature and antral follicle count (AFC), a standard measure of ovarian reserve.
designProspective cohort study.
settingFertility center at an academic hospital in the northeastern United States. PATIENT(S): 631 women attending the Massachusetts General Hospital Fertility Center (2005-2015) who participated in the Environment and Reproductive Health Study. INTERVENTION(S): Daily temperature at the women's residential address was estimated for the 90 days before their antral follicle scan using a spatially refined gridded climate data set. We evaluated the associations between temperature and AFC using Poisson regression with robust standard errors, adjusting for relative humidity, fine particulate matter exposure, age, education, smoking status, year and month of AFC, and diagnosis of diminished ovarian reserve and ovulation disorders. MAIN OUTCOME MEASURE(S): Antral follicle count as measured with transvaginal ultrasonography. RESULT(S): A 1°C increase in average maximum temperature during the 90 days before ovarian reserve testing was associated with a -1.6% (95% confidence interval [CI], -2.8, -0.4) lower AFC. Associations remained negative, but were attenuated, for average maximum temperature exposure in the 30 days (-0.9%, 95% CI, -1.8, 0.1) and 14 days (-0.8%, 95% CI, -1.6, 0.0) before AFC. The negative association between average maximum temperature and AFC was stronger in November through June than during the summer months, suggesting that timing of heat exposure and acclimatization to heat may be important factors to consider in future research. CONCLUSION(S): Exposure to higher temperatures was associated with lower ovarian reserve. These results raise concern that rising ambient temperatures worldwide may result in accelerated reproductive aging among women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.