Evidence map›Paper›PMID 34116702›Full record

ArticleCancer & metabolism2021

Mass spectrometry imaging of L-[ring-

Jianhua Cao, Benjamin Balluff, Martijn Arts, Ludwig J Dubois, Luc J C van Loon, Tilman M Hackeng, Hans M H van Eijk, Gert Eijkel, Lara R Heij, Zita Soons and 2 more

Abstract read
In one paragraph

Article in Cancer & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jianhua CaoMaastricht MultiModal Molecular Imaging institute (M4I), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.
Benjamin BalluffMaastricht MultiModal Molecular Imaging institute (M4I), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.
Martijn ArtsDepartment of General Surgery (NUTRIM), Maastricht University, Maastricht, The Netherlands.
Ludwig J DuboisThe M-Lab, Department of Precision Medicine (GROW), Maastricht University, Maastricht, The Netherlands.
Luc J C van LoonDepartment of Human Biology (NUTRIM), Maastricht University, Maastricht, The Netherlands.
Tilman M HackengDepartment of Biochemistry (CARIM), Maastricht University, Maastricht, The Netherlands.
Hans M H van EijkDepartment of General Surgery (NUTRIM), Maastricht University, Maastricht, The Netherlands.
Gert EijkelMaastricht MultiModal Molecular Imaging institute (M4I), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.
Lara R HeijDepartment of General Surgery (NUTRIM), Maastricht University, Maastricht, The Netherlands.
Zita SoonsDepartment of General Surgery (NUTRIM), Maastricht University, Maastricht, The Netherlands.
Steven W M Olde DaminkDepartment of General Surgery (NUTRIM), Maastricht University, Maastricht, The Netherlands.
Ron M A HeerenMaastricht MultiModal Molecular Imaging institute (M4I), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands. r.heeren@maastrichtuniversity.nl.ORCID http://orcid.org/0000-0002-6533-7179

Funding

China Scholarship Council No. 201706040068KWF Kankerbestrijding TRANSCAN 2; Grant No. 643638Province of Limburg LINK Program
6 · The paper itself

Abstract

backgroundMetabolic reprogramming is a common phenomenon in tumorigenesis and tumor progression. Amino acids are important mediators in cancer metabolism, and their kinetics in tumor tissue are far from being understood completely. Mass spectrometry imaging is capable to spatiotemporally trace important endogenous metabolites in biological tissue specimens. In this research, we studied L-[ring-

methodsWe investigated the L-[ring-

resultsThe dynamic changes in the spatial distributions of 19 out of 20 standard amino acids are observed in the tumor tissue. The highest abundance of

conclusionsWe demonstrated the spatiotemporal intra-tumoral distribution of the essential aromatic amino acid

Indexed as

Amino acidsIsotope labelingL-[ring-13C6]-PhenylalanineL-[ring-13C6]-TyrosineMass spectrometry imagingTumor

Identifiers

PMID34116702
PMCPMC8193875

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.