Evidence map›Paper›PMID 34116608›Full record

ArticleEpigenetics2022

Association of mammographic density with blood DNA methylation.

Rachel M Lucia, Wei-Lin Huang, Andrea Alvarez, Irene Masunaka, Argyrios Ziogas, Deborah Goodman, Andrew O Odegaard, Trina M Norden-Krichmar, Hannah Lui Park

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Rachel M LuciaDepartment of Epidemiology, University of California, Irvine, USA.
Wei-Lin HuangDepartment of Epidemiology, University of California, Irvine, USA.
Andrea AlvarezDepartment of Medicine, University of California, Irvine, USA.
Irene MasunakaDepartment of Medicine, University of California, Irvine, USA.
Argyrios ZiogasDepartment of Medicine, University of California, Irvine, USA.
Deborah GoodmanDepartment of Epidemiology, University of California, Irvine, USA.
Andrew O OdegaardDepartment of Epidemiology, University of California, Irvine, USA.
Trina M Norden-KrichmarDepartment of Epidemiology, University of California, Irvine, USA.
Hannah Lui ParkDepartment of Epidemiology, University of California, Irvine, USA.ORCID 0000-0001-9973-1396
University of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAltered DNA methylation may be an intermediate phenotype between breast cancer risk factors and disease. Mammographic density is a strong risk factor for breast cancer. However, no studies to date have identified an epigenetic signature of mammographic density. We performed an epigenome-wide association study of mammographic density.

methodsWhite blood cell DNA methylation was measured for 385 postmenopausal women using the Illumina Infinium MethylationEPIC BeadChip array. Differential methylation was assessed using genome-wide, probe-level, and regional analyses. We implemented a resampling-based approach to improve the stability of our findings.

resultsOn average, women with elevated mammographic density exhibited DNA hypermethylation within CpG islands and gene promoters compared to women with lower mammographic density. We identified 250 CpG sites for which DNA methylation was significantly associated with mammographic density. The top sites were located within genes associated with cancer, including

conclusionMammographic density is associated with differential DNA methylation throughout the genome, including within genes associated with cancer. Our results suggest the potential involvement of several genes in the biological mechanisms behind differences in breast density between women. Further studies are warranted to explore these potential mechanisms and potential links to breast cancer risk.

Indexed as

Breast DensityBreast NeoplasmsCpG IslandsDNA MethylationEpigenesis, GeneticEpigenomicsFemaleGenome-Wide Association StudyHumansbreast cancerDNA methylationepigeneticsepigenome-wide association studyillumina epic arraymammographic densitypostmenopausal

Identifiers

PMID34116608
PMCPMC9067527
OpenAlexW3173053717

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.