ArticleNeuroImage2021
Multi-modal imaging of a single mouse brain over five orders of magnitude of resolution.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- What needs to be standardized for reliable, reproducible, and robust tractography?GigaScience · 2026Review
- The pathogenesis of cerebral small vessel disease and vascular cognitive impairment.Physiological reviews · 2025Review
- Synchrotron Radiation-Based Tomography of an Entire Mouse Brain with Sub-Micron Voxels: Augmenting Interactive Brain Atlases with Terabyte Data.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Application of Synchrotron Radiation in Fundamental Research and Clinical Medicine.Biomedicines · 2025Review
- Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 3-Ex vivo imaging: Data processing, comparisons with microscopy, and tractography.Magnetic resonance in medicine · 2025Review
- Investigating microstructural changes between in vivo and perfused ex vivo marmoset brains using oscillating gradient and b-tensor encoded diffusion MRI at 9.4 T.Magnetic resonance in medicine · 2025Article
- Interplay between MRI-based axon diameter and myelination estimates in macaque and human brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Sub-MicroliterJournal of neurochemistry · 2025Article
- Non-parametric prediction of brain MRI microstructure using transfer learning.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Laminography as a tool for imaging large-size samples with high resolution.Journal of synchrotron radiation · 2024Article
- 3D imaging of SARS-CoV-2 infected hamster lungs by X-ray phase contrast tomography enables drug testing.Scientific reports · 2024Article
- Synchrotron-source micro-x-ray computed tomography for examining butterfly eyes.Ecology and evolution · 2024Article
- Bridging complexity through integrative systems neuroscience.Frontiers in systems biology · 2024Article
- Structural and functional imaging of brains.Science China. Chemistry · 2023Review
- Multiscale fluorescence imaging of living samples.Histochemistry and cell biology · 2022Review
- Review
- Functional and multiscale 3D structural investigation of brain tissue through correlative in vivo physiology, synchrotron microtomography and volume electron microscopy.Nature communications · 2022Article
- Article
- MTNeuro: A Benchmark for Evaluating Representations of Brain Structure Across Multiple Levels of Abstraction.Advances in neural information processing systems · 2022Article
- Synchrotron X-ray micro-CT as a validation dataset for diffusion MRI in whole mouse brain.Magnetic resonance in medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Mammalian neurons operate at length scales spanning six orders of magnitude; they project millimeters to centimeters across brain regions, are composed of micrometer-scale-diameter myelinated axons, and ultimately form nanometer scale synapses. Capturing these anatomical features across that breadth of scale has required imaging samples with multiple independent imaging modalities. Translating between the different modalities, however, requires imaging the same brain with each. Here, we imaged the same postmortem mouse brain over five orders of spatial resolution using MRI, whole brain micrometer-scale synchrotron x-ray tomography (μCT), and large volume automated serial electron microscopy. Using this pipeline, we can track individual myelinated axons previously relegated to axon bundles in diffusion tensor MRI or arbitrarily trace neurons and their processes brain-wide and identify individual synapses on them. This pipeline provides both an unprecedented look across a single brain's multi-scaled organization as well as a vehicle for studying the brain's multi-scale pathologies.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.