Evidence map›Paper›PMID 34115938›Full record

ArticleNano letters2021

Morphologic Design of Silver-Bearing Sugar-Based Polymer Nanoparticles for Uroepithelial Cell Binding and Antimicrobial Delivery.

Yue Song, Mahmoud Elsabahy, Christina A Collins, Sarosh Khan, Richen Li, Teri N Hreha, Yidan Shen, Yen-Nan Lin, Rachel A Letteri, Lu Su and 4 more

Abstract read
In one paragraph

Article in Nano letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yue SongDepartment of Chemistry, Department of Chemical Engineering, and Department of Materials Science & EngineeringTexas A&M University, College Station, Texas 77842, United States.ORCID 0000-0002-7800-5528
Mahmoud ElsabahyDepartment of Chemistry, Department of Chemical Engineering, and Department of Materials Science & EngineeringTexas A&M University, College Station, Texas 77842, United States.ORCID 0000-0003-3341-1829
Christina A Collins
Sarosh KhanDepartment of Chemistry, Department of Chemical Engineering, and Department of Materials Science & EngineeringTexas A&M University, College Station, Texas 77842, United States.
Richen LiDepartment of Chemistry, Department of Chemical Engineering, and Department of Materials Science & EngineeringTexas A&M University, College Station, Texas 77842, United States.
Teri N Hreha
Yidan ShenDepartment of Chemistry, Department of Chemical Engineering, and Department of Materials Science & EngineeringTexas A&M University, College Station, Texas 77842, United States.ORCID 0000-0001-9163-7530
Yen-Nan LinDepartment of Chemistry, Department of Chemical Engineering, and Department of Materials Science & EngineeringTexas A&M University, College Station, Texas 77842, United States.ORCID 0000-0001-7118-7771
Rachel A LetteriDepartment of Chemistry, Department of Chemical Engineering, and Department of Materials Science & EngineeringTexas A&M University, College Station, Texas 77842, United States.
Lu SuDepartment of Chemistry, Department of Chemical Engineering, and Department of Materials Science & EngineeringTexas A&M University, College Station, Texas 77842, United States.
Mei DongDepartment of Chemistry, Department of Chemical Engineering, and Department of Materials Science & EngineeringTexas A&M University, College Station, Texas 77842, United States.ORCID 0000-0002-9862-0296
Fuwu ZhangDepartment of Chemistry, Department of Chemical Engineering, and Department of Materials Science & EngineeringTexas A&M University, College Station, Texas 77842, United States.ORCID 0000-0002-1928-3472
David A Hunstad
Karen L WooleyDepartment of Chemistry, Department of Chemical Engineering, and Department of Materials Science & EngineeringTexas A&M University, College Station, Texas 77842, United States.ORCID 0000-0003-4086-384X

Funding

RENAL DISEASET32DK007126 · NIDDK · WASHINGTON UNIVERSITY · PI HUMPHREYS, BENJAMIN D. · 1986 to 2022
$5.2M
Mechanisms of maternal Immunoglobulin A control over the neonatal microbiota and the development of Necrotizing Enterocolitis.R01DK120697 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Timothy Wesley Hand · 2020 to 2026
$3.6M
Cellular and Molecular Basis of Sex Specificity in UTI PathogenesisR01DK126697 · NIDDK · WASHINGTON UNIVERSITY · PI EARL, ASHLEE MIRIAM, HUNSTAD, DAVID · 2020 to 2024
$2.5M
ANDROGEN INFLUENCE ON UTI SUSCEPTIBILITY AND SEVERITYR01DK111541 · NIDDK · WASHINGTON UNIVERSITY · PI HUNSTAD, DAVID · 2018 to 2021
$1.4M
ZEISS LSM880 AIRYSCAN MICROSCOPE FOR SHARED BIOMEDICAL RESEARCHS10OD021629 · OD · WASHINGTON UNIVERSITY · PI FITZPATRICK, JAMES ALEXANDER · 2017 to 2017
$596k
National Science Foundation CHE-1610311National Science Foundation CHE-2003771National Science Foundation DMREF-1629094NIDDK NIH HHS R01 DK111541NIDDK NIH HHS R01 DK120697NIDDK NIH HHS R01 DK126697NIDDK NIH HHS T32 DK007126NIDDK NIH HHS T32-DK007126NIH HHS S10 OD021629
6 · The paper itself

Abstract

Platelet-like and cylindrical nanostructures from sugar-based polymers are designed to mimic the aspect ratio of bacteria and achieve uroepithelial cell binding and internalization, thereby improving their potential for local treatment of recurrent urinary tract infections. Polymer nanostructures, derived from amphiphilic block polymers composed of zwitterionic poly(d-glucose carbonate) and semicrystalline poly(l-lactide) segments, were constructed with morphologies that could be tuned to enhance uroepithelial cell binding. These nanoparticles exhibited negligible cytotoxicity, immunotoxicity, and cytokine adsorption, while also offering substantial silver cation loading capacity, extended release, and

Indexed as

NanoparticlesPolymersAnti-Bacterial AgentsSilverSugarsAnti-Bacterial AgentsPolymersSilverSugarsantimicrobialcell-binding and internalizationplatelet-shaped nanostructuresSilver-bearing polymer nanostructuresurinary tract infections

Identifiers

PMID34115938
PMCPMC8545462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.