Evidence map›Paper›PMID 34115917›Full record

ReviewEuropean journal of neurology2021

Persistent visual dysfunction following posterior reversible encephalopathy syndrome due to COVID-19: Case series and literature review.

Alison M Hixon, Ashesh A Thaker, Victoria S Pelak

Open access · bronzeAbstract readReview
In one paragraph

Review in European journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. A review of neuro-ophthalmic sequelae following COVID-19 infection and vaccination.Frontiers in cellular and infection microbiology · 2024
    Review
  6. Article
  7. Advances in Management of the Stroke Etiology One-Percenters.Current neurology and neuroscience reports · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Complex Hallucinations in Hospitalized Rehabilitation Patients With COVID-19.Archives of rehabilitation research and clinical translation · 2022
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alison M HixonMedical Scientist Training Program, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-8373-4311
Ashesh A ThakerNeuroradiology Section, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0001-5238-0429
Victoria S PelakDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0003-3147-8595
University of Colorado Denver · USThe Medical Center of Aurora · US

Funding

The pathogenesis of enterovirus D68 CNS infectionF30AI136403 · NIAID · UNIVERSITY OF COLORADO DENVER · PI HIXON, ALISON MARISSA · 2018 to 2021
$117k
National Institute of Allergy and Infectious Diseases 5F30AI136403-03NIAID NIH HHS F30 AI136403
6 · The paper itself

Abstract

background and purposeThe full spectrum of neurological sequelae in COVID-19 is beginning to emerge. SARS-CoV-2 has the potential to cause both direct and indirect brain vascular endothelial damage through infection and inflammation that may result in long-term neurological signs and symptoms. We sought to illuminate persistent neuro-ophthalmological deficits that may be seen following posterior reversible encephalopathy syndrome (PRES) due to COVID-19.

methodsWe identified three individuals with PRES due to COVID-19 in our hospital system. One patient was identified on presentation to our neuro-ophthalmology clinic. The other patients were identified through internal records search. These cases were compared to published reports of PRES in COVID-19 identified through systematic literature search of PubMed/LitCOVID.

resultsAll three patients were hospitalized with severe COVID-19 and developed altered mental status with new onset seizures that led to the recognition of PRES through diagnostic imaging. During recovery, two patients had persistent visual dysfunction including visual field deficits. One patient also experienced hallucinatory palinopsia and visual hallucinations. Literature search identified 32 other cases of PRES in the context of COVID-19. Visual disturbances were described in 14 cases (40%), with only seven cases (50%) reporting full recovery by the time of publication.

conclusionsAs we learn about enduring neurological complications of COVID-19, it is possible that complications may be underrecognized and underreported. Understanding the range of complications can help in postcare evaluation and management changes in the critical care setting to potentially allow intervention before persistent deficits occur due to COVID-19.

Indexed as

COVID-19Posterior Leukoencephalopathy SyndromeCritical CareHumansSARS-CoV-2Vision Disorderscase seriesCOVID-19literature reviewpalinopsiaposterior reversible encephalopathy syndromePRESvisual field deficit

Identifiers

PMID34115917
PMCPMC8444757
OpenAlexW3167487745

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.