Evidence map›Paper›PMID 34115782›Full record

ArticlePloS one2021

Hybrid 2-[18F] FDG PET/MRI in premanifest Huntington's disease gene-expansion carriers: The significance of partial volume correction.

Marie N N Hellem, Tua Vinther-Jensen, Lasse Anderberg, Esben Budtz-Jørgensen, Lena E Hjermind, Vibeke Andrée Larsen, Jørgen E Nielsen, Ian Law

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. [European journal of nuclear medicine and molecular imaging · 2023
    Pooled it
  2. Review
  3. Article
  4. Review
  5. EANM procedure guidelines for brain PET imaging using [European journal of nuclear medicine and molecular imaging · 2022
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Marie N N HellemThe Neurogenetics Clinic, Danish Dementia Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-9026-1073
Tua Vinther-JensenThe Neurogenetics Clinic, Danish Dementia Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Lasse AnderbergDepartment of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Esben Budtz-JørgensenDepartment of Public Health, Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
Lena E HjermindThe Neurogenetics Clinic, Danish Dementia Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Vibeke Andrée LarsenDepartment of Radiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Jørgen E NielsenThe Neurogenetics Clinic, Danish Dementia Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Ian LawDepartment of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
University of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuntington's disease (HD) is an inherited, progressive neurodegenerative disease that has no cure. Striatal atrophy and hypometabolism has been described in HD as far as 15 years before clinical onset and therefore structural and functional imaging biomarkers are the most applied biomarker modalities which call for these to be exact; however, most studies are not considering the partial volume effect and thereby tend to overestimate metabolic reductions, which may bias imaging outcome measures of interventions.

objectiveEvaluation of partial volume effects in a cohort of premanifest HD gene-expansion carriers (HDGECs).

methods21 HDGECs and 17 controls had a hybrid 2-[18F]FDG PET/MRI scan performed. Volume measurements and striatal metabolism, both corrected and uncorrected for partial volume effect were correlated to an estimate of disease burden, the CAG age product scaled (CAPS).

resultsWe found significantly reduced striatal metabolism in HDGECs, but not in striatal volume. There was a negative correlation between the CAPS and striatal metabolism, both corrected and uncorrected for the partial volume effect. The partial volume effect was largest in the smallest structures and increased the difference in metabolism between the HDGEC with high and low CAPS scores. Statistical parametric mapping confirmed the results.

conclusionsA hybrid 2-[18F]FDG PET/MRI scan provides simultaneous information on structure and metabolism. Using this approach for the first time on HDGECs, we highlight the importance of partial volume effect correction in order not to underestimate the standardized uptake value and thereby the risk of overestimating the metabolic effect on the striatal structures, which potentially could bias studies determining imaging outcome measures of interventions in HDGECs and probably also symptomatic HD.

Indexed as

HeterozygoteAdultFemaleFluorodeoxyglucose F18HumansHuntingtin ProteinHuntington DiseaseMagnetic Resonance ImagingMaleMiddle AgedMultimodal ImagingPositron-Emission TomographyRadiopharmaceuticalsTrinucleotide Repeat ExpansionFluorodeoxyglucose F18HTT protein, humanHuntingtin ProteinRadiopharmaceuticals

Identifiers

PMID34115782
PMCPMC8195345
OpenAlexW3166962994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.