Evidence map›Paper›PMID 34115764›Full record

ArticlePLoS neglected tropical diseases2021

Cost of illness for severe and non-severe diarrhea borne by households in a low-income urban community of Bangladesh: A cross-sectional study.

Rebeca Sultana, Stephen P Luby, Emily S Gurley, Nadia Ali Rimi, Sayeda Tasnuva Swarna, Jahangir A M Khan, Nazmun Nahar, Probir Kumar Ghosh, Sushil Ranjan Howlader, Humayun Kabir and 2 more

3 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06839586 phase1 / phase2active not recruitingnot on this mapstarted 2025, after this paper: background citation

The Efficacy and Safety of CMTS4520 for Chronic Diarrhoea in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.

TypeinterventionalSponsorThe Second Hospital of Nanjing Medical UniversityRan2025 to 2030Enrolled100ConditionsDiarrhoeaArmsCMTS4520 (dietary fiber and probiotics), Placebo
NCT06839599 phase1 / phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Efficacy and Safety of CMTS4520-Assisted Washed Microbiota Transplantation for Chronic Diarrhoea in Adults: a Randomized, Double-Blind, Placebo-Controlled Trial.

TypeinterventionalSponsorThe Second Hospital of Nanjing Medical UniversityRan2025 to 2030Enrolled100ConditionsDiarrheaArmsCMTS4520 (dietary fiber probiotics), Placebo
NCT07767370 early_phase1recruitingnot on this mapstarted 2026, after this paper: background citation

A Randomised, Controlled, Double-blind Exploratory Study of ND-12 Combined With H-6 in the Treatment of Adult Chronic Inflammatory Diarrhea

TypeinterventionalSponsorThe Second Hospital of Nanjing Medical UniversityRan2026 to 2028Enrolled36ConditionsDiarrhea Chronic, UC - Ulcerative ColitisArmsmesalazine, ND-12, ND-12/H-6
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  5. Quantifying the Cost ofOpen forum infectious diseases · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 5 countries.

Rebeca SultanaDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-4180-5679
Stephen P LubyStanford University, Stanford, California, United States of America.ORCID 0000-0001-5385-899X
Emily S Gurleyicddr,b, Dhaka, Bangladesh.ORCID 0000-0002-8648-9403
Nadia Ali Rimiicddr,b, Dhaka, Bangladesh.
Sayeda Tasnuva Swarnaicddr,b, Dhaka, Bangladesh.
Jahangir A M KhanLiverpool School of Tropical Medicine, Liverpool, United Kingdom.
Nazmun NaharSwiss Tropical and Public Health Institute, Basel, Switzerland.
Probir Kumar Ghoshicddr,b, Dhaka, Bangladesh.ORCID 0000-0003-1580-5883
Sushil Ranjan HowladerInstitute of Health Economics, University of Dhaka, Dhaka, Bangladesh.
Humayun Kabiricddr,b, Dhaka, Bangladesh.
Shifat Khanicddr,b, Dhaka, Bangladesh.
Peter Kjær Mackie JensenDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-8856-2395
International Centre for Diarrhoeal Disease Research · BDUniversity of Copenhagen · DKJohns Hopkins University · USLiverpool School of Tropical Medicine · GBStanford University · USSwiss Tropical and Public Health Institute · CHUniversity of Dhaka · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The illness cost borne by households, known as out-of-pocket expenditure, was 74% of the total health expenditure in Bangladesh in 2017. Calculating economic burden of diarrhea of low-income urban community is important to identify potential cost savings strategies and prioritize policy decision to improve the quality of life of this population. This study aimed to estimate cost of illness and monthly percent expenditure borne by households due diarrhea in a low-income urban settlement of Dhaka, Bangladesh. We conducted this study in East Arichpur area of Tongi township in Dhaka, Bangladesh from September 17, 2015 to July 26, 2016. We used the World Health Organization (WHO) definition of three or more loose stool in 24 hours to enroll patients and enrolled 106 severe patients and 158 non-severe patients from Tongi General Hospital, local pharmacy and study community. The team enrolled patients between the first to third day of the illness (≤ 72 hours) and continued daily follow-up by phone until recovery. We considered direct and indirect costs to calculate cost-per-episode. We applied the published incidence rate to estimate the annual cost of diarrhea. The estimated average cost of illness for patient with severe diarrhea was US$ 27.39 [95% CI: 24.55, 30.23] (2,147 BDT), 17% of the average monthly income of the households. The average cost of illness for patient with non-severe diarrhea was US$ 6.36 [95% CI: 5.19, 7.55] (499 BDT), 4% of the average monthly income of households. A single diarrheal episode substantially affects financial condition of low-income urban community residents: a severe episode can cost almost equivalent to 4.35 days (17%) and a non-severe episode can cost almost equivalent to 1 day (4%) of household's income. Preventing diarrhea preserves health and supports financial livelihoods.

Indexed as

AdolescentAdultBangladeshChildChild, PreschoolCost of IllnessDiarrheaFamily CharacteristicsFemaleHealth Care CostsHumansInfantMalePovertyUrban PopulationYoung Adult

Identifiers

PMID34115764
PMCPMC8221788
OpenAlexW3168970705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.