Evidence map›Paper›PMID 34115429›Full record

ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging2021

Functional and morphological correlates of developmental dyslexia: A multimodal investigation of the ventral occipitotemporal cortex.

Valentina Borghesani, Cheng Wang, Christa Watson, Florence Bouhali, Eduardo Caverzasi, Giovanni Battistella, Rian Bogley, Nicole A Yabut, Jessica Deleon, Zachary A Miller and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Valentina BorghesaniDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-7909-8631
Cheng WangDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Christa WatsonDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Florence BouhaliDepartment of Psychiatry and Behavioral Science, University of California, San Francisco, San Francisco, California, USA.
Eduardo CaverzasiDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Giovanni BattistellaDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Rian BogleyDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Nicole A YabutDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Jessica DeleonDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Zachary A MillerDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Fumiko HoeftDepartment of Psychiatry and Behavioral Science, University of California, San Francisco, San Francisco, California, USA.
Maria Luisa MandelliDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Maria Luisa Gorno-TempiniDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
University of California, San Francisco · USMansfield University · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
Primary Progressive Aphasia: Beyond the Clinical VariantsK23DC018021 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DELEON, JESSICA ANNE · 2020 to 2024
$995k
NIA NIH HHS P01 AG019724NIA NIH HHS P50 AG023501NIDCD NIH HHS K23 DC018021NIDCD NIH HHS K24 DC015544NINDS NIH HHS R01 NS050915
6 · The paper itself

Abstract

background and purposeThe ventral occipitotemporal cortex (vOT) is a region crucial for reading acquisition through selective tuning to printed words. Developmental dyslexia is a disorder of reading with underlying neurobiological bases often associated with atypical neural responses to printed words. Previous studies have discovered anomalous structural development and function of the vOT in individuals with dyslexia. However, it remains unclear if or how structural abnormalities relate to functional alterations.

methodsIn this study, we acquired structural, functional (words and faces processing), and diffusion MRI data from 26 children with dyslexia (average age = 10.4 ± 2.0 years) and 14 age-matched typically developing readers (average age = 10.4 ± 1.6 years). Morphological indices of local gyrification, neurite density (i.e., dendritic arborization structure), and orientation dispersion (i.e., dendritic arborization orientation) were analyzed within the vOT region that showed preferential activation in typically developing readers for words (as compared to face stimuli).

resultsThe two cohorts diverged significantly in both functional and structural measures. Compared to typically developing controls, children with dyslexia did not show selectivity for words in the left vOT (contrast: words > false fonts). This lack of tuning to printed words was associated with greater neurite dispersion heterogeneity in the dyslexia cohort, but similar neurite density. These group differences were not present in the homologous contralateral area, the right vOT.

conclusionsOur findings provide new insight into the neurobiology of the lack of vOT word tuning in dyslexia by linking behavior, alterations in functional activation, and neurite organization.

Indexed as

DyslexiaMagnetic Resonance ImagingBrain MappingCerebral CortexChildHumansReadingdevelopmental dyslexiadiffusion MRIfunctional MRIneurite morphologyoccipitotemporal cortex

Identifiers

PMID34115429
PMCPMC10832296
OpenAlexW3167912436

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.