Evidence map›Paper›PMID 34115343›Full record

ArticlePharmacological reports : PR2021

Novel serotonin 5-HT

Anna Czopek, Monika Kubacka, Adam Bucki, Agata Siwek, Barbara Filipek, Maciej Pawłowski, Marcin Kołaczkowski

Open access · hybridAbstract read
In one paragraph

Article in Pharmacological reports : PR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Antischistosomal activity of imidazolidine-2,4-dione derivatives.Antimicrobial agents and chemotherapy · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anna CzopekDepartment of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland. anna.czopek@uj.edu.pl.ORCID http://orcid.org/0000-0002-1448-9826
Monika KubackaDepartment of Pharmacodynamics, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland.
Adam BuckiDepartment of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland.
Agata SiwekDepartment of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688, Krakow, Poland.
Barbara FilipekDepartment of Pharmacodynamics, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland.
Maciej PawłowskiDepartment of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland.
Marcin KołaczkowskiDepartment of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland.
Jagiellonian University · PL

Funding

Uniwersytet Jagielloński Collegium Medicum K/ZDS/006208Uniwersytet Jagielloński Collegium Medicum K/ZDS/006235Uniwersytet Jagielloński Collegium Medicum N42/DBS/000020Uniwersytet Jagielloński Collegium Medicum N42/DBS/000139
6 · The paper itself

Abstract

backgroundAntiplatelet drugs have been used in the treatment of acute coronary syndromes and for the prevention of recurrent events. Unfortunately, many patients remain resistant to the available antiplatelet treatment. Therefore, there is a clinical need to synthesize novel antiplatelet agents, which would be associated with different pathways of platelet aggregation, to develop an alternative or additional treatment for resistant patients. Recent studies have revealed that 5-HT

methodsBased on the structures of the conventional 5-HT

resultsFunctional bioassays revealed some of the synthesized compounds to be moderate antagonists of 5-HT

conclusionsOur study confirmed that the 5-HT

Indexed as

AnimalsAortaCHO CellsCricetinaeCricetulusHumansHydantoinsMianserinModels, MolecularMolecular StructurePlatelet Aggregation InhibitorsProtein ConformationRatsSerotonin 5-HT2 Receptor AntagonistsHydantoinsMianserinPlatelet Aggregation InhibitorsSerotonin 5-HT2 Receptor Antagonists5-HT2A receptorsAggregationAntiplateletHydantoinImidazolidinine-2,4-dione

Identifiers

PMID34115343
PMCPMC8460535
OpenAlexW3169406329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.