Evidence map›Paper›PMID 34115290›Full record

ArticleNeuromolecular medicine2022

Hypercapnia Modulates the Activity of Adenosine A1 Receptors and mitoK

P P Tregub, N A Malinovskaya, E D Osipova, A V Morgun, V P Kulikov, D A Kuzovkov

Abstract read
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In one paragraph

Article in Neuromolecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

P P TregubKrasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Partizan Zheleznyak st., 1., Krasnoyarsk, Russian Federation, 660022. pfiza_asmu@mail.ru.ORCID 0000-0002-3650-6121
N A MalinovskayaKrasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Partizan Zheleznyak st., 1., Krasnoyarsk, Russian Federation, 660022.
E D OsipovaKrasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Partizan Zheleznyak st., 1., Krasnoyarsk, Russian Federation, 660022.
A V MorgunKrasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Partizan Zheleznyak st., 1., Krasnoyarsk, Russian Federation, 660022.
V P KulikovAltai Medical Institute of Postgraduate Education, Polzunova st., 34a, Barnaul, Russian Federation, 656000.
D A KuzovkovKrasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Partizan Zheleznyak st., 1., Krasnoyarsk, Russian Federation, 660022.
Krasnoyarsk State Medical University · RUAltai State Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms and signaling pathways of the neuroprotective effects of hypercapnia and its combination with hypoxia are not studied sufficiently. The study aims to test the hypothesis of the potentiating effect of hypercapnia on the systems of adaptation to hypoxia, directly associated with A1-adenosine receptors and mitochondrial ATP-dependent K+ -channels (mitoK

Indexed as

HypercapniaPotassium ChannelsReceptor, Adenosine A1AnimalsCerebral CortexHypoxiaMaleRatsRats, Wistarmitochondrial K(ATP) channelPotassium ChannelsReceptor, Adenosine A1A1-adenosine receptorsHippocampusHypercapniaHypoxiamitoK+ ATP-channelsNeuroprotection

Identifiers

PMID34115290
OpenAlexW3172980828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.