Evidence map›Paper›PMID 34115247›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2021

Combined selective culture and molecular methods for the detection of carbapenem-resistant organisms from fecal specimens.

Rebecca Yee, Stefanie Fisher, Yehudit Bergman, Krizia K Chambers, Pranita D Tamma, Karen C Carroll, Patricia J Simner

Abstract readEvaluation Study
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In one paragraph

Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rebecca YeeDivision of Medical Microbiology, Johns Hopkins University School of Medicine, Meyer B1-193, 600 N. Wolfe Street, Baltimore, MD, USA.
Stefanie FisherDivision of Medical Microbiology, Johns Hopkins University School of Medicine, Meyer B1-193, 600 N. Wolfe Street, Baltimore, MD, USA.
Yehudit BergmanDivision of Medical Microbiology, Johns Hopkins University School of Medicine, Meyer B1-193, 600 N. Wolfe Street, Baltimore, MD, USA.
Krizia K ChambersDivision of Medical Microbiology, Johns Hopkins University School of Medicine, Meyer B1-193, 600 N. Wolfe Street, Baltimore, MD, USA.
Pranita D TammaDivision of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Karen C CarrollDivision of Medical Microbiology, Johns Hopkins University School of Medicine, Meyer B1-193, 600 N. Wolfe Street, Baltimore, MD, USA.
Patricia J SimnerDivision of Medical Microbiology, Johns Hopkins University School of Medicine, Meyer B1-193, 600 N. Wolfe Street, Baltimore, MD, USA. psimner1@jhmi.edu.ORCID http://orcid.org/0000-0001-6134-151X
Johns Hopkins University · US

Funding

CDC HHS 1U54CK000447NCEZID CDC HHS U54 CK000447
6 · The paper itself

Abstract

Detection of patients with intestinal colonization of carbapenem-resistant organisms (CRO), or more specifically carbapenemase-producing (CP) CRO, can prevent their transmission in healthcare facilities and aid with outbreak investigations. The objective of this work was to further develop and compare methods that combine selective culture and/or PCR to rapidly detect and recover CRO from fecal specimens. Molecularly characterized Gram-negative bacilli (n = 62) were used to spike fecal samples to establish limit of detection (LOD; n = 12), sensitivity (n = 28), and specificity (n= 21) for 3 methods to detect CP-CRO: direct MacConkey (MAC) plate and Xpert Carba-R (Cepheid) on growth, MAC broth and Carba-R testing of the broth, and direct testing by Carba-R. This was followed by a clinical study comparing methods in parallel for 286 fecal specimens. The LOD ranged from 10

Indexed as

Anti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsColony Count, MicrobialCross InfectionDrug Resistance, BacterialFecesGram-Negative BacteriaGram-Negative Bacterial InfectionsHumansPolymerase Chain ReactionSensitivity and SpecificityAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenemsCarbapenemaseCarbapenem-resistant organismsMethodsPublic healthSurveillance

Identifiers

PMID34115247
OpenAlexW3172052809

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.