ReviewBundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz2021
[Use of fluorides for caries prevention].
Review in Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Association between miR-21 polymorphism and the risk of primary dental caries in preschool children.Odontology · 2026Article
- Oral Health in Children With Congenital Heart Diseases: A Comprehensive Narrative Review.Clinical medicine insights. Pediatrics · 2026Review
- The Effect of Toothpaste Suspensions on the Formation of Oral Biofilms In Situ.International dental journal · 2026Article
- [Early dental visits - a systematic analysis of the information content of national dental child health records].Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) · 2025Article
- [Importance and supply of micronutrients in infants, children and adolescents].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2025Article
- The Remineralizing and Desensitizing Potential of Hydroxyapatite in Dentistry: A Narrative Review of Recent Clinical Evidence.Journal of functional biomaterials · 2025Review
- White Spot Lesion Treatment Options: A Systematic Review of Different Techniques for Masking These Lesions.Gels (Basel, Switzerland) · 2025Review
- Tooth brushing behavior and oral health care of people with early childhood autism in Germany.Clinical oral investigations · 2025Article
- Evaluation ofDentistry journal · 2024Article
- Nitrates of cerium and samarium deposit on human enamel independently of a salivary pellicle.Frontiers in oral health · 2024Article
- Essential oil-containing solutions (mouthwashes) preserve dental enamel with releasing low Ca and P concentrations without morphology alterations: anFrontiers in chemistry · 2024Article
- Xylitol Fluoride Varnish: In Vitro Effect Analysis on Enamel by Atomic Force Microscopy.Biomedicines · 2022Article
- Remineralization and protection from demineralization: effects of a hydroxyapatite-containing, a fluoride-containing and a fluoride- and hydroxyapatite-free toothpaste on human enamel in vitro.Head & face medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For a few decades, a decrease in the caries burden in all age groups has been observed in Germany. The regular use of fluoride preparations is described as the main reason for the caries decline. It is well established that topical fluoride application directly to the tooth surfaces in the oral cavity, in particular fluoride-containing toothpastes and fluoride varnishes, is responsible for the decline. Several mechanisms of action, such as the formation of a calcium fluoride layer, remineralization, and the effects on bacterial plaque, were determined to be responsible for the overall clinical effect. All these mechanisms can be effective on enamel and root dentin in patients of all ages. There is a dose-response relationship between the fluoride concentration in the applied preparations and the average caries reduction achieved.There are no general toxicological concerns about topical fluoride application. Fluoride toothpastes should be used from the eruption of the first deciduous tooth. The amount of toothpaste used should be limited to the recommended volumes to avoid the development of enamel fluorosis. The professionally performed application of highly concentrated fluoride varnishes, in addition to having a high caries-inhibiting effectiveness, also exhibits advantages in cases of increased caries risk and existing demineralization. This is also the case for the application on root dentin, where significant primary and secondary preventive effects have been demonstrated by application of highly concentrated fluoride preparations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.