ArticleAmerican journal of physiology. Heart and circulatory physiology2021
Reperfused vs. nonreperfused myocardial infarction: when to use which model.
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Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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30citing papers in PubMed, 1 pooled it
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guidelines for in vivo mouse models of myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2021Guideline
- Multi-omics analysis of early reperfused ischemic heart reveals ERRβ/γ activation protects against acute myocardial infarction injury.Journal of advanced research · 2026Article
- Growth Hormone-Releasing Peptide-6 (GHRP-6) Ameliorates Post-Infarct Ventricular Remodeling and Systolic Dysfunction in a Model of Permanent Coronary Ligation.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Cellular and molecular signals of cardiac wound healing after myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2026Review
- Acute myocardial infarction induces sex-specific, time-dependent remodeling of the gut microbiome and intestinal immune compartment in retired breeder C57BL/6N mice.Frontiers in microbiomes · 2026Article
- Review
- CD14 Blockade Modulates Macrophage-Mediated Immunological Injury in a Translational Model of Reperfused ST-Segment Elevation Myocardial Infarction.JACC. Basic to translational science · 2025Article
- Macro- and microinjury define the heart failure progression after permanent coronary ligation or ischemia-reperfusion in young healthy mice.American journal of physiology. Heart and circulatory physiology · 2025Article
- Mechanical regulation of macrophage metabolism by allograft inflammatory factor 1 leads to adverse remodeling after cardiac injury.Nature cardiovascular research · 2025Article
- Macrophage-specific lipoxygenase deletion amplify cardiac repair activating Treg cells in chronic heart failure.Journal of leukocyte biology · 2024Article
- 4D ultrasound-based strain assessment of cardiac dysfunction in male rats with reperfused and nonreperfused myocardial infarction.Physiological reports · 2024Article
- The heart-bone connection: relationships between myocardial infarction and osteoporotic fracture.American journal of physiology. Heart and circulatory physiology · 2024Review
- Ischemia-reperfusion myocardial infarction induces remodeling of left cardiac-projecting stellate ganglia neurons.American journal of physiology. Heart and circulatory physiology · 2024Article
- Control of the post-infarct immune microenvironment through biotherapeutic and biomaterial-based approaches.Drug delivery and translational research · 2023Review
- Spring cleaning: freshening up the portfolio.American journal of physiology. Heart and circulatory physiology · 2023Article
- Harnessing the Plasma Proteome to Mirror Current and Predict Future Cardiac Remodeling After Myocardial Infarction.Journal of cardiovascular translational research · 2023Article
- The cardiac wound healing response to myocardial infarction.WIREs mechanisms of disease · 2023Review
- Unraveling the role of galectin-3 in cardiac pathology and physiology.Frontiers in physiology · 2023Review
- Riding the wave: a quantitative report of electrocardiogram utilization for myocardial infarction confirmation.American journal of physiology. Heart and circulatory physiology · 2022Article
- Reevaluating methods reporting practices to improve reproducibility: an analysis of methodological rigor for the Langendorff whole heart technique.American journal of physiology. Heart and circulatory physiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Merry L LindseyDepartment of Cellular and Integrative Physiology, Center for Heart and Vascular Research, University of Nebraska Medical Center, Omaha, Nebraska.ORCID 0000-0002-4090-0391
Lisandra E de Castro BrásDepartment of Physiology, The Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Kristine Y DeLeon-PennellDivision of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.ORCID 0000-0002-9647-6112
Nikolaos G FrangogiannisDepartment of Medicine (Cardiology), The Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, New York.
Ganesh V HaladeDivision of Cardiovascular Sciences, Department of Medicine, University of South Florida, Tampa, Florida.ORCID 0000-0002-5351-9354
Caitlin C O'MearaDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Francis G SpinaleUniversity of South Carolina School of Medicine and Columbia Veteran Affairs HealthCare System, Columbia, South Carolina.
Zamaneh KassiriDepartment of Physiology, Cardiovascular Research Center, University of Alberta, Edmonton, Alberta, Canada.
Jonathan A KirkDepartment of Cell and Molecular Physiology, Loyola University Chicago Stritch School of Medicine, Chicago, Illinois.ORCID 0000-0002-5192-2860
Petra KleinbongardInstitute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, Essen, Germany.ORCID 0000-0003-3576-3772
Crystal M RipplingerDepartment of Pharmacology, UC Davis School of Medicine, Davis, California.ORCID 0000-0002-9908-4106
Keith R BruntDepartment of Pharmacology, Faculty of Medicine, Dalhousie University, Saint John, New Brunswick, Canada.ORCID 0000-0002-5728-8135
Funding
Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1MThe Role of Adrenergic Stimulation in ArrhythmogenesisR01HL111600 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Crystal May Ripplinger · 2012 to 2026
$7.1MGSK-3β Localizes to the Myofilament and Modifies its Function in Ischemic CardiomyopathyR01HL136737 · NHLBI · UNIVERSITY OF CHICAGO · PI JONATHAN A KIRK · 2017 to 2026
$4.5MUCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3MIL13 - A Novel Therapeutic Factor for Cardiac RegenerationR01HL141159 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI O'MEARA, CAITLIN C · 2019 to 2023
$2.1MSystems Biology of Fibroblast Activation Following Myocardial InfarctionR01HL129823 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI LINDSEY, MERRY L. · 2016 to 2019
$1.5MEffects of Adolescent Binge Alcohol Consumption on Cardiac Structure and FunctionR21AA027625 · NIAAA · LOYOLA UNIVERSITY CHICAGO · PI KIRK, JONATHAN A · 2019 to 2020
$387kReplacement of Small Animal Echocardiographic InstrumentationS10OD010417 · OD · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI ROSS, ROBERT SCOTT · 2012 to 2012
$371kCollagen-derived peptides to target inflammation in myocardial infarctionR56HL152297 · NHLBI · EAST CAROLINA UNIVERSITY · PI DE CASTRO BRAZ, LISANDRA E · 2020 to 2020
$366kT-cell regulation of cardiac remodelingIK2BX003922 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI DELEON-PENNELL, KRISTINE Y · 2017 to 2022
–BLRD VA IK2 BX003922Canadian Institute of Health Research PJT-37522,PJT-153306,PJT-421341,PJO-413883HHS | NIH | Office of Extramural Research, National Institutes of Health (OER) AA027625,GM115458,HL076246,HL085440,HL111600,HL129823HHS | NIH | Office of Extramural Research, National Institutes of Health (OER) HL132989,HL136737,HL137319,HL141159,HL144788,HL145817HHS | NIH | Office of Extramural Research, National Institutes of Health (OER) HL147570,HL149407,HL152297NHLBI NIH HHS R01 HL111600NHLBI NIH HHS R01 HL129823NHLBI NIH HHS R01 HL136737NHLBI NIH HHS R01 HL141159NHLBI NIH HHS R25 HL145817NHLBI NIH HHS R56 HL152297NHLBI NIH HHS T32 HL007444NIAAA NIH HHS R21 AA027625NIH HHS S10 OD010417
Abstract
There is a lack of understanding in the cardiac remodeling field regarding the use of nonreperfused myocardial infarction (MI) and reperfused MI in animal models of MI. This Perspectives summarizes the consensus of the authors regarding how to select the optimum model for your experiments and is a part of ongoing efforts to establish rigor and reproducibility in cardiac physiology research.
Indexed as
Myocardial InfarctionMyocardial IschemiaMyocardial ReperfusionAnimalsDisease Models, AnimalHeartcardiaccardiomyocyteischemia-reperfusionmyocardial infarctionrigor and reproducibility
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.