Evidence map›Paper›PMID 34114658›Full record

ArticleEuropean journal of immunology2021

Characterization of antifungal C-type lectin receptor expression on murine epithelial and endothelial cells in mucosal tissues.

Mark H T Stappers, Christina Nikolakopoulou, Darin L Wiesner, Raif Yuecel, Bruce S Klein, Janet A Willment, Gordon D Brown

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Lung Epithelial Cell Line Immune Responses toJournal of fungi (Basel, Switzerland) · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mark H T StappersAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.ORCID 0000-0003-4154-7160
Christina NikolakopoulouAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Darin L WiesnerDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Raif YuecelIain Fraser Cytometry Centre, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Bruce S KleinDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Janet A WillmentAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Gordon D BrownAberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.ORCID 0000-0002-0287-5383
University of Aberdeen · GBUniversity of Wisconsin–Madison · US

Funding

RESEARCH TRAINING IN HEMATOLOGYT32HL007899 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Jane Ellen Churpek · 1998 to 2026
$8.2M
Molecular Pathogenesis of BlastomycosisR37AI035681 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BRUCE Steven KLEIN · 2004 to 2026
$6.9M
Medical Research Council MR/N006364/2NHLBI NIH HHS T32 HL007899NIAID NIH HHS R37 AI035681Wellcome Trust 102705Wellcome Trust 102705/Z/13/ZWellcome Trust 217163
6 · The paper itself

Abstract

Our data reveal that selection of enzymes for generating single cell suspensions from murine tissues influences detection of surface expression of antifungal CLRs. Using a method that most preserves receptor expression, we show that non-myeloid expression of antifungal CLRs is limited to MelLec on endothelial cells in murine mucosal tissues.

Indexed as

AnimalsAspergillusCandidaCryptococcusEndothelial CellsEpithelial CellsFungiLectins, C-TypeMiceMucous MembraneLectins, C-TypeC-type lectinEndothelial cellsEpithelial cellsImmunity, Innate

Identifiers

PMID34114658
PMCPMC8593890
OpenAlexW3167746077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.