ArticleAlimentary pharmacology & therapeutics2021
Characterisation of patients with supine nighttime reflux: observations made with prolonged wireless oesophageal pH monitoring.
Article in Alimentary pharmacology & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review: Clinical effectiveness of interventions for the treatment of nocturnal gastroesophageal reflux.Neurogastroenterology and motility · 2022Pooled it
- A comparative study of magnetic sphincter augmentation and Nissen fundoplication in the management of GERD.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Characterisation of patients with supine nighttime reflux: observations made with prolonged wireless oesophageal pH monitoring.Alimentary pharmacology & therapeutics · 2021Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough nighttime reflux symptoms are common, the presence of nocturnal reflux is seldom confirmed with a standard 24 hours pH study.
aimTo study patients with supine nighttime reflux symptoms using prolonged wireless pH monitoring.
methodsIn this retrospective study, patients with typical acid reflux symptoms were studied using 96-h pH monitoring. Patients with nighttime reflux symptoms were compared to those without. Night-to-night variability and diagnostic accuracy of 24-, 48- and 72-hours pH studies compared to the 96-hours "gold standard" were evaluated.
resultsOf the 105 included patients (61.9% females; mean age 46.8 ± 14.4 years), 86 (81.9%) reported nighttime reflux symptoms, of which 67.4% had pathological supine nocturnal acid exposure in at least one night. There was high variance in night-to-night acid exposure (94% [IQR0-144]), which was larger than the variance in upright acid exposure (58% [IQR32-88]; P < 0.001). When analysing the first 24 hours of the pH study, 32% of patients were diagnosed with pathological supine nighttime acid exposure versus 51% of patients based upon the 96-hours pH-test. The diagnostic accuracy and yield improved with study duration (P < 0.001). Reflux episodes with a lower nadir pH or longer acid clearance time were more prone to provoke nightly symptoms.
conclusionsThe majority of patients with nocturnal reflux symptoms had pathological acid exposure in at least one night of the prolonged pH recording. A high night-to-night variability in acid exposure reduces the clinical value and diagnostic yield of pH monitoring limited to 24 hours. Prolonged testing is a more appropriate diagnostic tool for patients with nocturnal reflux symptoms.
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