ArticleJournal of geriatric psychiatry and neurology2022
Prodromal Dementia With Lewy Bodies: Evolution of Symptoms and Predictors of Dementia Onset.
Article in Journal of geriatric psychiatry and neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The prevalence of apathy in Lewy body dementia: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Research diagnostic criteria for mild cognitive impairment with Lewy bodies: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Pooled it
- Increased granulovacuolar degeneration in the thalamus and higher neurofibrillary tangle Braak stages in bipolar disorder.Psychiatry and clinical neurosciences · 2025Article
- Cognitive Fluctuation Scale in Non-demented Patients with Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Features of Prodromal Parkinson Disease and Dopaminergic Neurotransmission in Community-Dwelling Older Adults.Neurology · 2025Observational
- Neural Basis of Anxiety in Dementia With Lewy Bodies.International journal of geriatric psychiatry · 2025Article
- Implications and opportunities regarding biological frameworks in overt and prodromal dementia with Lewy bodies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Validation of the neuropathological criteria of the fourth Consortium on dementia with Lewy Bodies in autopsy cases from psychiatric hospitals.Psychiatry and clinical neurosciences · 2025Article
- Clinical implication of anemia in older patients with dementia with lewy bodies.Aging clinical and experimental research · 2025Article
- Distinguishing Prodromal Dementia With Lewy Bodies From Prodromal Alzheimer Disease: A Longitudinal Study.Neurology. Clinical practice · 2025Article
- Toward a biological definition of neuronal and glial synucleinopathies.Nature medicine · 2025Review
- Challenges in the diagnosis and management of depressive and cognitive disorders in older adults: a case report.Dementia & neuropsychologia · 2025Article
- Risk factors and predictors for Lewy body dementia: a systematic review.NPJ dementia · 2025Article
- Key motor and non-motor features in early dementia with Lewy bodies.Frontiers in neurology · 2025Article
- Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer's disease.GeroScience · 2024Article
- The Association Between Major Depression and Alzheimer's Disease Risk: Evidence from a 12-Year Longitudinal Study.Journal of clinical medicine · 2024Article
- Severe psychiatric disorders are associated with increased risk of dementia.BMJ mental health · 2024Article
- Factors Associated With Increased Health Care Utilization for Patients With Dementia With Lewy Bodies: A Narrative Review.Journal of patient-centered research and reviews · 2024Review
- Advances in the Diagnosis and Management of Psychotic Symptoms in Neurodegenerative Diseases: A Narrative Review.Journal of geriatric psychiatry and neurology · 2023Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundResearch criteria for prodromal dementia with Lewy bodies (DLB) were published in 2020, but little is known regarding prodromal DLB in clinical settings.
methodsWe identified non-demented participants without neurodegenerative disease from the National Alzheimer's Coordinating Center Uniform Data Set who converted to DLB at a subsequent visit. Prevalence of neuropsychiatric and motor symptoms were examined up to 5 years prior to DLB diagnosis.
resultsThe sample included 116 participants clinically diagnosed with DLB and 348 age and sex-matched (1:3) Healthy Controls. Motor slowing was present in approximately 70% of participants 3 years prior to DLB diagnosis. In the prodromal phase, 50% of DLB participants demonstrated gait disorder, 70% had rigidity, 20% endorsed visual hallucinations, and over 50% of participants endorsed REM sleep behavior disorder. Apathy, depression, and anxiety were common prodromal neuropsychiatric symptoms. The presence of 1+ core clinical features of DLB in combination with apathy, depression, or anxiety resulted in the greatest AUC (0.815; 95% CI: 0.767, 0.865) for distinguishing HC from prodromal DLB 1 year prior to diagnosis. The presence of 2+ core clinical features was also accurate in differentiating between groups (AUC = 0.806; 95% CI: 0.756, 0.855).
conclusionA wide range of motor, neuropsychiatric and other core clinical symptoms are common in prodromal DLB. A combination of core clinical features, neuropsychiatric symptoms and cognitive impairment can accurately differentiate DLB from normal aging prior to dementia onset.
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