Evidence map›Paper›PMID 34114369›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Cytokines: From Clinical Significance to Quantification.

Chao Liu, Dewei Chu, Kourosh Kalantar-Zadeh, Jacob George, Howard A Young, Guozhen Liu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 476 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
476citing papers in PubMed, 4 pooled it
42.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

476 citing papers in PubMed, 4 syntheses or guidelines pooled it, 857 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Review
  7. Article
  8. Article
  9. Prognostic significance of pre-intervention circulating cytokines in digestive system cancers: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  10. Electropolymerized Aptasensor for Femtogram-Level Cytokine Detection.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review

416 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Chao LiuSchool of Materials Science and Engineering, University of New South Wales, Sydney, NSW, 2052, Australia.
Dewei ChuSchool of Materials Science and Engineering, University of New South Wales, Sydney, NSW, 2052, Australia.
Kourosh Kalantar-ZadehSchool of Chemical Engineering, University of New South Wales, Sydney, NSW, 2052, Australia.
Jacob GeorgeStorr Liver Centre, Westmead Institute of Medical Research, University of Sydney and Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, 2145, Australia.
Howard A YoungLaboratory of Cancer Immunometabolism, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, 21702, USA.
Guozhen LiuSchool of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, 518172, P. R. China.ORCID 0000-0002-0556-6404
UNSW Sydney · AUFrederick National Laboratory for Cancer Research · USThe University of Sydney · AU

Funding

Control of Cytokine Gene Expression in LymphoidMyeloid CellsZIABC009283 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI YOUNG, HOWARD · 2009 to 2024
$22.7M
Australian Government Research Training Program ScholarshipAustralian Research Council FT160100039Biomedical Engineering Seed FundCCR NIH HHS HHSN261200800001CChinese University of Hong Kong (Shenzhen) Development FundNCI NIH HHS HHSN261200800001ENIH HHSUniversity of New South WalesUNSW-CAS Collaborative Research Seed Fund Program 172644KYSB20190059U.S. Department of Health and Human Services
6 · The paper itself

Abstract

Cytokines are critical mediators that oversee and regulate immune and inflammatory responses via complex networks and serve as biomarkers for many diseases. Quantification of cytokines has significant value in both clinical medicine and biology as the levels provide insights into physiological and pathological processes and can be used to aid diagnosis and treatment. Cytokines and their clinical significance are introduced from the perspective of their pro- and anti-inflammatory effects. Factors affecting cytokines quantification in biological fluids, native levels in different body fluids, sample processing and storage conditions, sensitivity to freeze-thaw, and soluble cytokine receptors are discussed. In addition, recent advances in in vitro and in vivo assays, biosensors based on different signal outputs and intracellular to extracellular protein expression are summarized. Various quantification platforms for high-sensitivity and reliable measurement of cytokines in different scenarios are discussed, and commercially available cytokine assays are compared. A discussion of challenges in the development and advancement of technologies for cytokine quantification that aim to achieve real-time multiplex cytokine analysis for point-of-care situations applicable for both biomedical research and clinical practice are discussed.

Indexed as

BiomarkersCytokinesHumansBiomarkersCytokinesbiosensorsclinical significancecytokinesin vitro and in vivo assaysquantification

Identifiers

PMID34114369
PMCPMC8336501
OpenAlexW3170771910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.