Evidence map›Paper›PMID 34114350›Full record

ArticleChemMedChem2021

A Novel Minor Groove Binder as a Potential Therapeutic Agent for Myotonic Dystrophy Type 1.

Ke Li, Sarah B Krueger, Steven C Zimmerman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ke LiDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S Mathews Avenue, 61801, Urbana, IL, USA.ORCID 0000-0003-3851-7710
Sarah B KruegerDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S Mathews Avenue, 61801, Urbana, IL, USA.
Steven C ZimmermanDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S Mathews Avenue, 61801, Urbana, IL, USA.ORCID 0000-0002-5333-3437
University of Illinois Urbana-Champaign · US

Funding

Small Molecule Approaches to Targeting the DNA and RNA in Myotonic DystrophyR01AR069645 · NIAMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ZIMMERMAN, STEVEN C. · 2017 to 2021
$2.2M
Targeting CUG Expansions for the Treatment of Myotonic DystrophyR01AR058361 · NIAMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI HERGENROTHER, PAUL, ZIMMERMAN, STEVEN C. · 2009 to 2013
$1.7M
Graduate Research Fellow Program DGE01746047NIAMS NIH HHS R01 AR058361NIAMS NIH HHS R01 AR069645US National Science Foundation
6 · The paper itself

Abstract

Myotonic dystrophy type 1 (DM1) is a multisystemic neuromuscular disorder that is inherited in an autosomal dominant manner. DM1 originates in a (CTG⋅CAG) repeat expansion in the 3'-UTR of the dystrophia myotonic protein kinase (DMPK) gene on chromosome 19. One of the transcripts, r(CUG)

Indexed as

Dose-Response Relationship, DrugHumansLigandsMolecular Dynamics SimulationMolecular StructureMyotonic DystrophyPeptidomimeticsSmall Molecule LibrariesStructure-Activity RelationshipThiazolesTriazinesTrinucleotide RepeatsLigandsPeptidomimeticsSmall Molecule LibrariesThiazolesTriazinesDNA/RNA recognitionminor groove bindersmyotonic dystrophythiazoletriaminotriazine

Identifiers

PMID34114350
PMCPMC8429064
OpenAlexW3171665883

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.