Evidence map›Paper›PMID 34114323›Full record

ArticleHIV medicine2021

Urinary biomarkers of early renal injury in antiretroviral-naïve HIV-positive persons in Shanghai, China: comparison with the general population.

X Q Le, D P Liu, J Chen, Z Y Gong, J N Xun, J R Wang, J J Sun, C Steinhart, L Liu, Y Z Shen and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HIV medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

X Q LeDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
D P LiuDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID 0000-0001-8345-2069
J ChenDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID 0000-0001-9659-2669
Z Y GongSchool of Clinical Medicine, Jiamusi University, Jamusi, China.
J N XunScientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID 0000-0003-3781-5900
J R WangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
J J SunDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
C SteinhartCAN Community Health, Sarasota, FL, USA.
L LiuDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Y Z ShenDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID 0000-0002-7604-5139
T K QiDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Z Y WangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
X ZhangDepartment of Implant Dentistry, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Y TangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
W SongDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
H Z LuDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
R F ZhangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPeople living with HIV (PLWH) have a high risk of kidney injury. Measurement of serum creatinine, along with proteinuria, is not sensitive to detect early kidney injury. Here, we investigated novel urinary biomarkers of early renal injury in PLWH.

methodsWe performed a cross-sectional study of 166 antiretroviral-naïve PLWH and 99 HIV-negative persons who all had an estimated glomerular filtration rate > 90 mL/min/1.73 m

resultsEighty-three pairs were successfully matched based on PSM. Compared with the HIV-negative group, the HIV-positive group had higher ratios of N-acetyl-β-D-glucosaminidase (NAG) to urine creatinine (UCr), alpha1-microglobulin (α1-M) to UCr, kidney injury marker-1 (KIM-1) to UCr, neutrophil gelatinase-associated lipocalin to UCr, and epidermal growth factor to UCr, whereas the Tamm-Horsfall protein to UCr ratio and the abnormal albumin to UCr ratio were not significantly different. Positive correlations were observed between HIV RNA level and NAG: UCr (r

conclusionsIn comparioson with HIV-negative participants, PLWH were more likely to have tubular injury. Early antiretroviral treatment might mitigate the development of kidney injury.

Indexed as

HIV InfectionsBiomarkersChinaCross-Sectional StudiesHumansKidneyLipocalin-2BiomarkersLipocalin-2HIV infectionkidney injurypropensity score matchingurinary biomarkers

Identifiers

PMID34114323
PMCPMC8453740

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