Evidence map›Paper›PMID 34114268›Full record

ArticleEuropean journal of heart failure2021

Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC EORP PPCM Registry.

Alice M Jackson, Mark C Petrie, Alexandra Frogoudaki, Cécile Laroche, Finn Gustafsson, Bassem Ibrahim, Alexandre Mebazaa, Mark R Johnson, Petar M Seferovic, Vera Regitz-Zagrosek and 14 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 20 institutions in 17 countries.

Alice M JacksonBHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
Mark C PetrieBHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
Alexandra FrogoudakiSecond Cardiology Department, Attikon University Hospital, Athens, Greece.
Cécile LarocheEORP, European Society of Cardiology, Sophia Antipolis, France.
Finn GustafssonDepartment of Cardiology, Rigshospitalet, Copenhagen, Denmark.
Bassem IbrahimDepartment of Cardiology, North Cumbria University Hospital, Carlisle, UK.
Alexandre MebazaaUMR 942 Inserm - MASCOT; University of Paris, APHP Saint Louis Lariboisière University Hospitals, Department of Anesthesia-Burn-Critical Care, Paris, France.
Mark R JohnsonDepartment of Obstetrics, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, UK.
Petar M SeferovicUniversity of Belgrade Faculty of Medicine, Serbian Academy of Sciences and Arts, Belgrade, Serbia.
Vera Regitz-ZagrosekBerlin Institute of Gender in Medicine (GiM) - Charité, Universitätsmedizin, Berlin, Germany.
Amam MbakwemDepartment of Medicine, College of Medicine, University of Lagos and Lagos University Teaching Hospital, Lagos, Nigeria.
Michael BöhmKlinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Saarland University, Homburg, Germany.
Hawani S PrameswariDepartment of Cardiology and Vascular Medicine, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia.
Doaa A FouadDepartment of Cardiovascular Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.
Sorel GolandKaplan Medical Center, Rehovot, Hebrew University, Jerusalem, Israel.
Albertino DamascenoFaculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
Kamilu KarayeDepartment of Medicine, Bayero University & Aminu Kano Teaching Hospital, Kano, Nigeria.
Hasan A FarhanScientific Council of Cardiology, Iraqi Board for Medical Specializations, Baghdad Heart Center, Baghdad, Iraq.
Righab HamdanDepartment of Cardiology, Beirut Cardiac Institute, Beirut, Lebanon.
Aldo P MaggioniEORP, European Society of Cardiology, Sophia Antipolis, France.
Karen SliwaCape Heart Institute, Department of Medicine and Cardiology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Johann BauersachsDepartment of Cardiology and Angiology, Medical School Hannover, Hannover, Germany.
Peter van der MeerDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
PPCM Investigators Group
European Society of Cardiology · FRAssiut University · EGBaghdad Medical City · IQBayero University Kano · NGBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEChelsea and Westminster Hospital · GBEduardo Mondlane University · MZGolden Jubilee National Hospital · GBKaplan Medical Center · ILLagos University Teaching Hospital · NGMedizinische Hochschule Hannover · DEOrient-Institut Beirut · LBPadjadjaran University · IDRigshospitalet · DKSerbian Academy of Sciences and Arts · RSTiGenix (Spain) · ESUniversitätsklinikum des Saarlandes · DEUniversité Paris Cité · FRUniversity General Hospital Attikon · GRUniversity of Cape Town · ZA

Funding

British Heart Foundation 18/6/34217British Heart Foundation FS/18/14/33330
6 · The paper itself

Abstract

aimsHypertensive disorders occur in women with peripartum cardiomyopathy (PPCM). How often hypertensive disorders co-exist, and to what extent they impact outcomes, is less clear. We describe differences in phenotype and outcomes in women with PPCM with and without hypertensive disorders during pregnancy. METHODS AND

resultsThe European Society of Cardiology EURObservational Research Programme PPCM Registry enrolled women with PPCM from 2012-2018. Three groups were examined: (i) women without hypertension (PPCM-noHTN); (ii) women with hypertension but without pre-eclampsia (PPCM-HTN); (iii) women with pre-eclampsia (PPCM-PE). Maternal (6-month) and neonatal outcomes were compared. Of 735 women included, 452 (61.5%) had PPCM-noHTN, 99 (13.5%) had PPCM-HTN and 184 (25.0%) had PPCM-PE. Compared to women with PPCM-noHTN, women with PPCM-PE had more severe symptoms (New York Heart Association class IV in 44.4% vs. 29.9%, P < 0.001), more frequent signs of heart failure (pulmonary rales in 70.7% vs. 55.4%, P = 0.002), a higher baseline left ventricular ejection fraction (LVEF) (32.7% vs. 30.7%, P = 0.005) and a smaller left ventricular end-diastolic diameter (57.4 ± 6.7 mm vs. 59.8 ± 8.1 mm, P = 0.001). There were no differences in the frequencies of death from any cause, rehospitalization for any cause, stroke, or thromboembolic events. Compared to women with PPCM-noHTN, women with PPCM-PE had a greater likelihood of left ventricular recovery (LVEF ≥ 50%) (adjusted odds ratio 2.08, 95% confidence interval 1.21-3.57) and an adverse neonatal outcome (composite of termination, miscarriage, low birth weight or neonatal death) (adjusted odds ratio 2.84, 95% confidence interval 1.66-4.87).

conclusionDifferences exist in phenotype, recovery of cardiac function and neonatal outcomes according to hypertensive status in women with PPCM.

Indexed as

CardiomyopathiesHeart FailureHypertension, Pregnancy-InducedPregnancy Complications, CardiovascularFemaleHumansPeripartum PeriodPregnancyRegistriesStroke VolumeVentricular Function, LeftHeart failureHypertensionPeripartum cardiomyopathyPre-eclampsiaPregnancy

Identifiers

PMID34114268
PMCPMC9311416
OpenAlexW3169672359

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.