ArticleJournal of veterinary internal medicine2021
Neurofilament light chain as a biomarker of meningoencephalitis of unknown etiology in dogs.
Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- Investigation of Serum Neurofilament Light Chain as a Surrogate for Cerebrospinal Fluid Neurofilament Light Chain in Canine Cognitive Dysfunction Syndrome.Animals : an open access journal from MDPI · 2026Article
- Bridging gaps in mitochondrial disease diagnosis: the role of advanced biomarker discovery.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Plasma and cerebrospinal fluid biomarkers in aged dogs with cognitive decline.BMC veterinary research · 2025Article
- Diagnostic and Prognostic Value of Serum Neurofilament Light Chain in Canine Spinal Cord Diseases.Veterinary sciences · 2025Article
- Evaluation of Blood-Based Diagnostic Biomarkers for Canine Cognitive Dysfunction Syndrome.Animals : an open access journal from MDPI · 2025Article
- Neurofilament light chain (Nf-L) in cerebrospinal fluid and serum as a potential biomarker in the differential diagnosis of neurological diseases in cattle.Veterinary research · 2025Article
- On the utility of cerebrospinal fluid biomarkers in canine neurological disorders.Scientific reports · 2024Article
- Plasma Neurofilament Light Chains as Blood-Based Biomarkers for Early Diagnosis of Canine Cognitive Dysfunction Syndrome.International journal of molecular sciences · 2023Article
- Predictive Value of Acute Phase Proteins for the Short-Term Outcome of Meningoencephalitis of Unknown Origin in Dogs.Animals : an open access journal from MDPI · 2023Article
- Association between neurofilament light chain concentration and lesion size in dogs with meningoencephalitis of unknown origin.Veterinary medicine and science · 2023Article
- Cerebrospinal fluid and serum proteomic profiles accurately distinguish neuroaxonal dystrophy from cervical vertebral compressive myelopathy in horses.Journal of veterinary internal medicine · 2023Article
- New insights into the treatment of meningoencephalomyelitis of unknown origin since 2009: A review of 671 cases.Frontiers in veterinary science · 2023Review
- Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs.Frontiers in veterinary science · 2023Article
- Neurofilament light chain as a biomarker of meningoencephalitis of unknown etiology in dogs.Journal of veterinary internal medicine · 2021Article
- Use of neurofilament light chain to identify structural brain diseases in dogs.Journal of veterinary internal medicineArticle
- Evaluation of neurofilament light chain as a biomarker in dogs with structural and idiopathic epilepsy.Journal of veterinary internal medicineArticle
- Clinical presentation, diagnosis, treatment, and outcome in 8 dogs and 2 cats with global hypoxic-ischemic brain injury (2010-2022).Journal of veterinary internal medicineArticle
- Development of a reliable clinical assessment tool for meningoencephalitis in dogs: The neurodisability scale.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNeurofilament light chain (NfL) is a neuron-specific cytoskeletal protein expressed in axons. Damaged axons of the central nervous system release NfLs into the cerebrospinal fluid (CSF) and the blood. In humans with neurologic diseases, NfL is used as a biomarker.
objectivesTo identify the potential of NfL as a supportive tool for the diagnosis, prognosis, and monitoring of meningoencephalitis of unknown etiology (MUE) in dogs. ANIMALS: Twenty-six client-owned healthy dogs, 10 normal Beagle dogs, and 38 client-owned MUE dogs.
methodsCohort study. The concentrations of NfL in serum and CSF were measured using single-molecule array technology.
resultsMedian NfL concentration was significantly higher in MUE dogs (serum, 125 pg/mL; CSF, 14 700 pg/mL) than in healthy dogs (serum, 11.8 pg/mL, P < .0001; CSF, 1410 pg/mL, P = .0002). The areas under the receiver operating characteristic curves of serum and CSF NfL concentrations were 0.99 and 0.95, respectively. The cut-off values were 41.5 pg/mL (serum) and 4005 pg/mL (CSF) for differentiating between healthy and MUE dogs, with sensitivities of 89.19% and 90%, respectively, and specificities of 96.97% and 100%, respectively. The NfL concentration showed a significant decrease (pretreatment, 122 pg/mL; posttreatment, 36.6 pg/mL; P = .02) in the good treatment-response group and a significant increase (pretreatment, 292.5 pg/mL; posttreatment, 1880 pg/mL, P = .03) in the poor treatment-response group. CONCLUSIONS AND CLINICAL IMPORTANCE: Neurofilament light chain is a potential biomarker for diagnosing MUE and evaluating response to treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.