Evidence map›Paper›PMID 34114153›Full record

ArticleDigestive diseases and sciences2022

Surgery and the Subtype of Inflammatory Bowel Disease Impact the Risk of Venous Thromboembolism After Hospital Discharge.

Jeffrey D McCurdy, M Ellen Kuenzig, Sarah Spruin, Oliver W Fung, Ranjeeta Mallik, Lara Williams, Sanjay K Murthy, Marc Carrier, Geoff Nguyen, Eric I Benchimol

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In one paragraph

Article in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Are IBD Patients Underscored when Determining Postoperative VTE Risk?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
    Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Jeffrey D McCurdyDepartment of Medicine, University of Ottawa, Ottawa, Canada. jmccurdy@toh.ca.ORCID 0000-0002-0658-3062
M Ellen KuenzigCHEO Inflammatory Bowel Disease Centre, Division of Gastroenterology Hepatology and Nutrition, Children's Hospital of Eastern Ontario, Ottawa, Canada.
Sarah SpruinICES uOttawa, Ottawa, Canada.
Oliver W FungDepartment of Medicine, University of Ottawa, Ottawa, Canada.
Ranjeeta MallikThe Ottawa Hospital Research Institute, Ottawa, Canada.
Lara WilliamsThe Ottawa Hospital Research Institute, Ottawa, Canada.
Sanjay K MurthyDepartment of Medicine, University of Ottawa, Ottawa, Canada.
Marc CarrierDepartment of Medicine, University of Ottawa, Ottawa, Canada.
Geoff NguyenDepartment of Medicine, University of Toronto, Toronto, Canada.
Eric I BenchimolCHEO Inflammatory Bowel Disease Centre, Division of Gastroenterology Hepatology and Nutrition, Children's Hospital of Eastern Ontario, Ottawa, Canada.
University of Ottawa · CAChildren's Hospital of Eastern Ontario · CAMount Sinai Hospital · CAOttawa Hospital · CAUniversity of Toronto · CA

Funding

CIHR
6 · The paper itself

Abstract

backgroundSurgery for inflammatory bowel disease (IBD) is associated with an increased risk of venous thromboembolism (VTE) during hospitalization. It is unclear whether this association persists after hospital discharge.

aimsWe assessed the association between surgery and VTE following hospital discharge in IBD.

methodsWe conducted a population-based cohort study between 2002 and 2016 in Ontario, Canada. Adults with IBD hospitalized for ≥ 72 h who underwent an intra-abdominal surgery were compared to hospitalized, nonsurgical IBD patients. Multivariable Cox proportional hazard models were used to compare VTE risk within 12 months of discharge.

resultsA total of 80,445 hospital discharges were analyzed: 60% Crohn's disease (CD) and 40% ulcerative colitis (UC). The median time to VTE was three times longer for nonsurgical patients with CD and 1.6 times longer for nonsurgical patients with UC. Compared with nonsurgical patients, surgery for CD was associated with a lower cumulative risk of VTE in the 2 weeks after discharge and persisted through to 12 months after discharge (adjusted HR 0.24; 95% CI 0.15-0.40). In contrast, urgent surgery for UC was associated with an increased risk of VTE. The increased risk was greatest at 2 weeks after discharge (aHR, 1.80; 95% CI 1.26-2.57) and declined progressively over the course of 12 months.

conclusionsSurgery was associated with a greater risk of VTE after hospital discharge in UC but not CD. In patients with UC who have undergone urgent surgery, healthcare providers should consider an extended period of prophylaxis after hospital discharge.

Indexed as

Colitis, UlcerativeCrohn DiseaseInflammatory Bowel DiseasesVenous ThromboembolismAdultChronic DiseaseCohort StudiesHospitalsHumansPatient DischargeRisk FactorsExtended prophylaxisIBD complicationsThrombosis

Identifiers

PMID34114153
OpenAlexW3171809697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.