Evidence map›Paper›PMID 34114094›Full record

ReviewInsights into imaging2021

Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe.

Domenico Albano, Massimo Benenati, Antonio Bruno, Federico Bruno, Marco Calandri, Damiano Caruso, Diletta Cozzi, Riccardo De Robertis, Francesco Gentili, Irene Grazzini and 10 more

Open access · goldAbstract readReview
In one paragraph

Review in Insights into imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.

  1. Pooled it
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  4. Dosimetry of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
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  6. The role of stem cells in precision medicine: next-generation cancer treatment.Journal of the Egyptian National Cancer Institute · 2025
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  19. Potency and Safety ofClinical Medicine Insights. Oncology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 15 institutions in 1 country.

Domenico AlbanoIRCCS Istituto Ortopedico Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy. albanodomenico@me.com.ORCID http://orcid.org/0000-0001-7989-9861
Massimo BenenatiItalian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, Via della Signora 2, 20122, Milan, Italy.
Antonio BrunoDiagnostic and Interventional Radiology Unit, Maggiore Hospital "C. A. Pizzardi", 40133, Bologna, Italy.
Federico BrunoItalian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, Via della Signora 2, 20122, Milan, Italy.
Marco CalandriRadiology Unit, A.O.U. San Luigi Gonzaga di Orbassano, Department of Oncology, University of Torino, 10043, Turin, Italy.
Damiano CarusoDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome - Sant'Andrea University Hospital, Via di Grottarossa, 1035-1039, 00189, Rome, Italy.
Diletta CozziItalian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, Via della Signora 2, 20122, Milan, Italy.
Riccardo De RobertisU.O.C. Radiologia BT, Ospedale Civile Maggiore - Azienda Ospedaliera Universitaria Integrata Verona, Piazzale A. Stefani 1, 37126, Verona, Italy.
Francesco GentiliUnit of Diagnostic Imaging, Department of Radiological Sciences, University of Siena, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.
Irene GrazziniDepartment of Radiology, Section of Neuroradiology, San Donato Hospital, Arezzo, Italy.
Giuseppe MicciSezione di Scienze Radiologiche, Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata, Università Degli Studi di Palermo, Via del Vespro 127, 90127, Palermo, Italy.
Anna PalmisanoExperimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Carlotta PessinaDepartment of Radiology, University of Brescia, Piazzale Spedali Civili 1, 25123, Brescia, Italy.
Paola ScaliseDepartment of Diagnostic Imaging, Pisa University Hospital, Via Paradisa 2, 56124, Pisa, Italy.
Federica VernuccioSezione di Scienze Radiologiche, Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata, Università Degli Studi di Palermo, Via del Vespro 127, 90127, Palermo, Italy.
Antonio BarileDepartment of Biotechnology and Applied Clinical Sciences, University of L'Aquila, 67100, L'Aquila, Italy.
Vittorio MieleDepartment of Emergency Radiology, University Hospital Careggi, Largo Brambilla 3, 50123, Florence, Italy.
Roberto GrassiItalian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, Via della Signora 2, 20122, Milan, Italy.
Carmelo MessinaIRCCS Istituto Ortopedico Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy.
Young SIRM Working Group
Istituto Ortopedico Galeazzi · ITUniversity of L'Aquila · ITAgostino Gemelli University Polyclinic · ITAzienda Ospedaliero-Universitaria Careggi · ITSocietà Italiana di Reumatologia · ITUniversity of Siena · ITVita-Salute San Raffaele University · ITAzienda Ospedaliera Universitaria Integrata Verona · ITOspedale San Luigi Gonzaga · ITUniversity of Brescia · ITUniversity of Palermo · ITOspedale Maggiore Carlo Alberto Pizzardi · ITOspedale San Donato · ITSapienza University of Rome · ITUniversity of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Newer biologic drugs and immunomodulatory agents, as well as more tolerated and effective radiation therapy schemes, have reduced treatment toxicity in oncology patients. However, although imaging assessment of tumor response is adapting to atypical responses like tumor flare, expected changes and complications of chemo/radiotherapy are still routinely encountered in post-treatment imaging examinations. Radiologists must be aware of old and newer therapeutic options and related side effects or complications to avoid a misinterpretation of imaging findings. Further, advancements in oncology research have increased life expectancy of patients as well as the frequency of long-term therapy-related side effects that once could not be observed. This pictorial will help radiologists tasked to detect therapy-related complications and to differentiate expected changes of normal tissues from tumor relapse.

Indexed as

ChemotherapyComplicationsMagnetic resonance imagingRadiotherapySide effects

Identifiers

PMID34114094
PMCPMC8192650
OpenAlexW3166221064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.