ArticleThe Journal of nutrition2021
Plant-Based Diet Index and Metabolic Risk in Men: Exploring the Role of the Gut Microbiome.
Article in The Journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Effect of Sustainably Sourced Protein Consumption on Nutrient Intake and Gut Health in Older Adults: A Systematic Review.Nutrients · 2024Pooled it
- Associations between plant-based dietary patterns and risks of type 2 diabetes, cardiovascular disease, cancer, and mortality - a systematic review and meta-analysis.Nutrition journal · 2023Pooled it
- The Gut Microbiome as a Mechanistic Link Between the Planetary Health Diet and Healthy Aging.Nutrients · 2026Review
- Healthful plant-based diet, gut enterotype, and cognition in a rural Chinese elderly cohort: A longitudinal multi-omics study.Cell reports. Medicine · 2026Article
- Plant-based diet quality and gut microbiota in relation to cardiometabolic risk in Korean adults.European journal of nutrition · 2026Article
- Development and External Validation of the Cantonese Dietary Index: A Population-Based Approach to Assess Diet Quality and Metabolic Risk.Nutrients · 2026Article
- A nutritionally informed model for Bayesian variable selection with metabolite response variables.Biostatistics (Oxford, England) · 2026Article
- Group-wise normalization in differential abundance analysis of microbiome samples.BMC bioinformatics · 2025Article
- Diet-Gut Microbiota Relations: Critical Appraisal of Evidence From Studies Using Metagenomics.Nutrition reviews · 2025Review
- Plant-based diets and mortality in Black and low-income Americans: findings from a large prospective cohort study.The American journal of clinical nutrition · 2025Article
- Plant-based diet, inflammation biomarkers and body composition among women with breast cancer: the Pathways Study.The British journal of nutrition · 2025Article
- Pomegranate-Derived Exosome-Like Nanovesicles Containing Ellagic Acid Alleviate Gut Leakage and Liver Injury in MASLD.Food science & nutrition · 2025Article
- Multiomics approach reveals the comprehensive interactions between nutrition and children's gut microbiota, and microbial and host metabolomes.Nutrition journal · 2025Article
- Dietary patterns influencing the human colonic microbiota from infancy to centenarian age: a narrative review.Frontiers in nutrition · 2025Review
- Machine learning integrates region-specific microbial signatures to distinguish geographically adjacent populations within a province.Frontiers in microbiology · 2025Article
- A Qualitative Study of Rural Plant-Based Eaters' Knowledge and Practices for Nutritional Adequacy.Nutrients · 2024Article
- Review
- From Garden to Pillow: Understanding the Relationship between Plant-Based Nutrition and Quality of Sleep.Nutrients · 2024Review
- A plant-based diet index to study the relation between diet and disease risk among adults: a narrative review.The journal of nutrition, health & aging · 2024Review
- Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundHealthy plant-based diet index (hPDI) is associated with a lower risk of cardiometabolic conditions, but its association as well as interactions with microbiome have not been elucidated.
objectivesWe aimed to investigate the interrelations between hPDI, gut microbiome, and cardiometabolic risk markers.
methodshPDI was derived from dietary assessments by a validated FFQ and was examined in relation to metagenomic profiles of 911 fecal samples collected from 303 men aged 71 ± 4 y with an average BMI (in kg/m2) of 25.2 ± 3.6 in the Men's Lifestyle Validation Study. Principal coordinate (PCo) analysis based on Bray-Curtis dissimilarity was conducted, and interactions between hPDI and PCo were examined by using a metabolic risk score composed of blood lipids, BMI, and glycated hemoglobin.
resultsAfter multivariable adjustment, hPDI was significantly associated with the relative abundance of 7 species and 9 pathways. In particular, higher hPDI was significantly associated with a higher relative abundance of Bacteroides cellulosilyticus and Eubacterium eligens, amino acid biosynthesis pathways (l-isoleucine biosynthesis I and III and l-valine biosynthesis), and the pathway of pyruvate fermentation to isobutanol. A favorable association between hPDI and the metabolic risk score was more pronounced among men with a higher PCo characterized by higher abundance of Bacteroides uniformis and lower abundance of Prevotella copri. At the individual species level, a similar interaction was also observed between hPDI and P. copri, as well as with Clostridium clostridioforme or Blautia hydrogenotrophica (all P-interaction < 0.01).
conclusionA greater adherence to a healthy plant-based diet by older men was associated with a microbial profile characterized by a higher abundance of multiple species, including B. cellulosilyticus and E. eligens, as well as pathways in amino acid metabolism and pyruvate fermentation. In addition, inverse associations between healthy plant-based diet and human metabolic risk may partially depend on microbial compositions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.