Evidence map›Paper›PMID 34113890›Full record

ArticleHeart rhythm O22020

Evaluation of subcutaneous implantable cardioverter-defibrillator performance in patients with ion channelopathies from the EFFORTLESS cohort and comparison with a meta-analysis of transvenous ICD outcomes.

Pier D Lambiase, Lars Eckardt, Dominic A Theuns, Timothy R Betts, Andreas L Kyriacou, Elizabeth Duffy, Reinoud Knops

Open access · goldAbstract read
In one paragraph

Article in Heart rhythm O2, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Outcome of patients with idiopathic ventricular fibrillation and correlation with ECG markers of early repolarization.Clinical research in cardiology : official journal of the German Cardiac Society · 2023
    Article
  3. Modern subcutaneous implantable defibrillator therapy in patients with cardiomyopathies and channelopathies: data from a large multicentre registry.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  4. Review
  5. Article
  6. Impact of SMART Pass filter in patients with ajmaline-induced Brugada syndrome and subcutaneous implantable cardioverter-defibrillator eligibility failure: results from a prospective multicentre study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022
    Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 4 countries.

Pier D LambiaseBarts Heart Centre, London, Edgware, United Kingdom.
Lars EckardtDepartment of Cardiology II, University Hospital, Muenster, Germany.
Dominic A TheunsErasmus MC, Rotterdam, Netherlands.
Timothy R BettsOxford Biomedical Research Centre, Oxford, United Kingdom.
Andreas L KyriacouSheffield Teaching Hospitals, Sheffield, United Kingdom.
Elizabeth DuffyBoston Scientific, St Paul, Minnesota.
Reinoud KnopsAcademic Medical Center, Amsterdam, Netherlands.
Academic Medical Center · NLBoston Scientific (United States) · USEdgware Community Hospital · GBErasmus University Rotterdam · NLOxford BioMedica (United Kingdom) · GBSheffield Teaching Hospitals NHS Foundation Trust · GBUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe subcutaneous implantable cardioverter-defibrillator (S-ICD) is an alternative to conventional transvenous ICD (TV-ICD) therapy to reduce lead complications.

objectiveTo evaluate outcomes in channelopathy vs patients with structural heart disease in the EFFORTLESS-SICD Registry and with a previously reported TV-ICD meta-analysis in channnelopathies.

methodsThe EFFORTLESS registry includes 199 patients with channelopathies (Brugada syndrome 83, long QT syndrome 24, idiopathic ventricular fibrillation 78, others 14) and 786 patients with structural heart disease.

resultsChannelopathy patients were younger (39 ± 14 years vs 51 ± 17 years;

conclusionEFFORTLESS demonstrates similar S-ICD efficacy and a nonsignificant, lower rate of IAS in channelopathy patients as compared to structural heart disease. Comparable IAS rates were achieved with the device programmed to higher rates for channelopathy patients.

Indexed as

ArrhythmiaChannelopathyImplantable cardioverter-defibrillatorSubcutaneous ICDSudden cardiac deathVentricular arrhythmias

Identifiers

PMID34113890
PMCPMC8183957
OpenAlexW3096113947

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.