Evidence map›Paper›PMID 34113866›Full record

ArticleHeart rhythm O22020

Novel beta-blocker pretreatment prevents alcohol-induced atrial fibrillation in a rat model.

Hebah Hassan, Lisa V Greco, Daniel I Meshoyrer, Ying Li, Youhua Zhang, Todd J Cohen

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm O2, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hebah HassanDepartment of Clinical Specialties, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York.
Lisa V GrecoDepartment of Clinical Specialties, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York.
Daniel I MeshoyrerDepartment of Clinical Specialties, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York.
Ying LiDepartment of Clinical Specialties, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York.
Youhua ZhangDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York.
Todd J CohenDepartment of Clinical Specialties, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York.
New York Institute of Technology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA case report published in 2019 described a patient who presented with difficult-to-manage atrial fibrillation (AF) that consistently was associated with alcohol consumption. After the patient did not respond to drug therapy, a novel beta-blocker (BB) pretreatment regimen initiated immediately before alcohol consumption successfully prevented AF occurrence.

objectiveThe purpose of this study was to test the hypothesis that a novel prophylactic BB therapy given before alcohol consumption could prevent AF in a rat model.

methodsAn alcohol-induced AF model was developed in adult Sprague-Dawley rats of both sexes by administering alcohol (2 g/kg intraperitoneal [IP]) once every other day for a total of 4 times. Three groups were enrolled: alcohol (EtOH; n = 10); alcohol plus BB (metoprolol 50 mg/kg IP) pretreatment (EtOH+BB; n = 10); and control (n = 9). Cardiac function (assessed by echocardiography and left ventricular hemodynamics) and

resultsAll but 1 rat completed the study. Alcohol exposure did not significantly impact cardiac function and the atrial effective refractory period. However, alcohol exposure significantly increased AF inducibility [median (first and third quartile [Q1-Q3]) 0% (0%-0%) in control vs 60% (25%-100%) in the EtOH group;

conclusionMetoprolol pretreatment before alcohol administration significantly decreased AF induction in rats. These findings suggest that BB pretreatment is a promising prophylaxis regimen for alcohol-induced AF.

Indexed as

AlcoholAtrial fibrillationAtrial fibrillation inducibilityBeta-blockerEffective refractory period

Identifiers

PMID34113866
PMCPMC8183851
OpenAlexW3026753436

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.