Evidence map›Paper›PMID 34113861›Full record

ArticleHeart rhythm O22020

Implantable cardioverter-defibrillator programming after first occurrence of ventricular tachycardia in the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT).

Mehmet K Aktas, Amanda L Bennett, Arwa Younis, Valentina Kutyifa, Bronislava Polonsky, Scott McNitt, Wojciech Zareba, Spencer Rosero, Ilan Goldenberg

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm O2, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Contemporary management of ventricular arrhythmias in heart failure.American journal of cardiovascular disease · 2023
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mehmet K AktasClinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York.
Amanda L BennettClinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York.
Arwa YounisClinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York.
Valentina KutyifaClinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York.
Bronislava PolonskyClinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York.
Scott McNittClinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York.
Wojciech ZarebaClinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York.
Spencer RoseroClinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York.
Ilan GoldenbergClinical Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York.
University of Rochester Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImplantable cardioverter-defibrillator (ICD) programming to novel settings can reduce the risk of inappropriate therapies.

objectiveThe purpose of this study was to evaluate the impact of novel ICD programming after the first occurrence of ventricular tachycardia (VT).

methodsIn MADIT-RIT (Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy) patients who experienced a first occurrence of VT, the risk of subsequent inappropriate and appropriate ICD therapies and adverse cardiovascular events by ICD programming to Arm A (conventional: VT ≥170 bpm), Arm B (high rate: VT ≥200 bpm), or Arm C (duration delay: ≥60-second delay before therapy ≥170 bpm) was determined.

resultsAmong 205 patients, ICD programming changes were made in 30 patients (15%) after they experienced a VT episode; 117 patients (57%) were programmed to Arm A settings and 88 patients (43%) to Arm B/C settings. At 15-month follow-up, the cumulative probability of inappropriate ICD therapy was significantly lower in Arm B/C compared to Arm A (9% vs 20%; log-rank

conclusionThe benefit of high-rate cutoff or duration delay settings in patients with an ICD is maintained after the first occurrence of VT.

Indexed as

Heart failureImplantable cardioverter-defibrillator programmingImplantable cardioverter-defibrillator shockInappropriate implantable cardioverter-defibrillator shockVentricular tachycardia

Identifiers

PMID34113861
PMCPMC8183956
OpenAlexW3024918289

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.