Evidence map›Paper›PMID 34113853›Full record

ArticleHeart rhythm O22020

Atrial fibrillation detection from raw photoplethysmography waveforms: A deep learning application.

Kirstin Aschbacher, Defne Yilmaz, Yaniv Kerem, Stuart Crawford, David Benaron, Jiaqi Liu, Meghan Eaton, Geoffrey H Tison, Jeffrey E Olgin, Yihan Li and 1 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Heart rhythm O2, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. The 2023 wearable photoplethysmography roadmap.Physiological measurement · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kirstin AschbacherDivision of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, California.
Defne YilmazDivision of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, California.
Yaniv KeremJawbone Health, San Francisco, California.
Stuart CrawfordJawbone Health, San Francisco, California.
David BenaronJawbone Health, San Francisco, California.
Jiaqi LiuJawbone Health, San Francisco, California.
Meghan EatonJawbone Health, San Francisco, California.
Geoffrey H TisonDivision of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, California.
Jeffrey E OlginDivision of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, California.
Yihan LiJawbone Health, San Francisco, California.
Gregory M MarcusDivision of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, California.
Jawbone (United States) · USUniversity of California, San Francisco · US

Funding

Dynamic prediction of heart failure using real-time functional status and EHR data in the ambulatory settingK23HL135274 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TISON, GEOFFREY H · 2018 to 2022
$999k
NHLBI NIH HHS K23 HL135274
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF), a common cause of stroke, often is asymptomatic. Smartphones and smartwatches can detect AF using heart rate patterns inferred using photoplethysmography (PPG); however, enhanced accuracy is required to reduce false positives in screening populations.

objectiveThe purpose of this study was to test the hypothesis that a deep learning algorithm given raw, smartwatch-derived PPG waveforms would discriminate AF from normal sinus rhythm better than algorithms using heart rate alone.

methodsPatients presenting for cardioversion of AF (n = 51) were given wrist-worn fitness trackers containing PPG sensors (Jawbone Health). Standard 12-lead electrocardiograms over-read by board-certified cardiac electrophysiologists were used as the reference standard. The accuracy of PPG signals to discriminate AF from sinus rhythm was evaluated by conventional measures of heart rate variability, a long short-term memory (LSTM) neural network given heart rate data only, and a deep convolutional-recurrent neural net (DNN) given the raw PPG data.

resultsFrom among 51 patients with persistent AF (age 63.6 ± 11.3 years; 78% male; 88% white), we randomly assigned 40 to train and 11 to test the algorithms. Whereas logistic regression analysis of heart rate variability yielded an area under the receiver operating characteristic curve (AUC) of 0.717 (sensitivity 0.741; specificity 0.584), the LSTM model given heart rate data exhibited AUC of 0.954 (sensitivity 0.810; specificity 0.921), and the DNN model given raw PPG data yielded the highest AUC of 0.983 (sensitivity 0.985; specificity 0.880).

conclusionA deep learning model given the raw PPG-based signal resulted in AF detection with high accuracy, performing better than conventional analyses relying on heart rate series data alone.

Indexed as

Artificial intelligenceAtrial fibrillationHeart rate sensorMachine learningMobile healthPhotoplethysmographySmartwatchWearable

Identifiers

PMID34113853
PMCPMC8183963
OpenAlexW3017994033

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.