ArticleiScience2021
Scaling relation between genome length and particle size of viruses provides insights into viral life history.
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Why did some viruses evolve to be giants while others did not?Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Unveiling the biodiversity of large DNA viruses in intertidal mudflats via metagenomics.Nature communications · 2026Article
- Comparative Analysis Reveals Host Species-Dependent Diversity Among 16 Virulent Bacteriophages Isolated Against SoybeanViruses · 2025Article
- Comparative Analysis Reveals Host Species-Dependent Diversity Among 16 Virulent Bacteriophages Isolated Against SoybeanbioRxiv : the preprint server for biology · 2025Article
- Hybrid sequencing reveals the genome of a Chrysochromulina parva virus and highlight its distinct replication strategy.BMC genomics · 2025Article
- Diversity and evolution of prokaryotic viral lytic proteins.The ISME journal · 2025Article
- Genome sizes of animal RNA viruses reflect phylogenetic constraints.Virus evolution · 2025Article
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- Structure and replication cycle of a virus infecting climate-modulating algaScience advances · 2024Article
- A comparison of short-read, HiFi long-read, and hybrid strategies for genome-resolved metagenomics.Microbiology spectrum · 2024Article
- Gene duplication as a major force driving the genome expansion in some giant viruses.Journal of virology · 2023Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In terms of genome and particle sizes, viruses exhibit great diversity. With the discovery of several nucleocytoplasmic large DNA viruses (NCLDVs) and jumbo phages, the relationship between particle and genome sizes has emerged as an important criterion for understanding virus evolution. We use allometric scaling of capsid volume with the genome length of different groups of viruses to shed light on its relationship with virus life history. The allometric exponents for icosahedral dsDNA bacteriophages and NCDLVs were found to be 1 and 2, respectively, indicating that with increasing capsid size DNA packaging density remains the same in bacteriophages but decreases for NCLDVs. We argue that the exponents are largely shaped by their entry mechanism and capsid mechanical stability. We further show that these allometric size parameters are also intricately linked to the relative energy costs of translation and replication in viruses and can have further implications on viral life history.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.