Evidence map›Paper›PMID 34113777›Full record

ArticleContact (Thousand Oaks (Ventura County, Calif.))2020

Lipid Droplet Contacts With Autophagosomes, Lysosomes, and Other Degradative Vesicles.

Kristina Drizyte-Miller, Micah B Schott, Mark A McNiven

Open access · goldAbstract read
In one paragraph

Article in Contact (Thousand Oaks (Ventura County, Calif.)), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Essential Biology of Lipid Droplets.Annual review of biochemistry · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Lipophagy at a glance.Journal of cell science · 2022
    Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Biogenesis and Breakdown of Lipid Droplets in Pathological Conditions.Frontiers in cell and developmental biology · 2021
    Review
  20. Direct lysosome-based autophagy of lipid droplets in hepatocytes.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kristina Drizyte-MillerBiochemistry and Molecular Biology Program, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota, United States.
Micah B SchottDivision of Gastroenterology and Hepatology, Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-2396-5038
Mark A McNivenDivision of Gastroenterology and Hepatology, Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States.
Mayo Clinic · US

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI MARK A. MC NIVEN · 2009 to 2026
$22.2M
Altered Lipid Droplet Trafficking: Role in Alcoholic Fatty Liver DiseaseR01AA020735 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CASEY, CAROL A., MC NIVEN, MARK A. · 2011 to 2025
$8.1M
CYTOSKELETAL REGULATION OF VESICLE TRANSPORT IN LIVERR01DK044650 · NIDDK · MAYO CLINIC ROCHESTER · PI MC NIVEN, MARK A. · 1997 to 2020
$3.3M
Synergy of lipolysis and lipophagy in alcoholic liver diseaseK99AA026877 · NIAAA · MAYO CLINIC ROCHESTER · PI SCHOTT, MICAH · 2019 to 2021
$388k
NIAAA NIH HHS K99 AA026877NIAAA NIH HHS R01 AA020735NIDDK NIH HHS P30 DK084567NIDDK NIH HHS R01 DK044650
6 · The paper itself

Abstract

Lipid droplets (LDs) are dynamic fat-storage organelles that interact readily with numerous cellular structures and organelles. A prominent LD contact site is with degradative vesicles such as autophagosomes, lysosomes, autolysosomes, and late endosomes. These contacts support lipid catabolism through the selective autophagy of LDs (i.e., lipophagy) or the recruitment of cytosolic lipases to the LD surface (i.e., lipolysis). However, LD-autophagosome contacts serve additional functions beyond lipid catabolism, including the supply of lipids for autophagosome biogenesis. In this review, we discuss the molecular mediators of LD contacts with autophagosomes and other degradative organelles as well as the diverse cellular functions of these contact sites in health and disease.

Indexed as

autophagosomeautophagycell biologyendosomelipid dropletlysosome

Identifiers

PMID34113777
PMCPMC8188833
OpenAlexW3010681214

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.