Evidence map›Paper›PMID 34113740›Full record

ArticleGene reports2020

Serotonin transporter untranslated regions influence mRNA abundance and protein expression.

Christopher Manzella, Megha Singhal, Max Ackerman, Waddah A Alrefai, Seema Saksena, Pradeep K Dudeja, Ravinder K Gill

Open access · greenAbstract read
In one paragraph

Article in Gene reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Christopher ManzellaDepartment of Physiology & Biophysics, University of Illinois at Chicago, Chicago, IL, United States of America.
Megha SinghalDivision of Gastroenterology & Hepatology, University of Illinois at Chicago, Chicago, IL, United States of America.
Max AckermanUniversity of Illinois at Chicago, College of Liberal Arts and Sciences, United States of America.
Waddah A AlrefaiDivision of Gastroenterology & Hepatology, University of Illinois at Chicago, Chicago, IL, United States of America.
Seema SaksenaDivision of Gastroenterology & Hepatology, University of Illinois at Chicago, Chicago, IL, United States of America.
Pradeep K DudejaDivision of Gastroenterology & Hepatology, University of Illinois at Chicago, Chicago, IL, United States of America.
Ravinder K GillDivision of Gastroenterology & Hepatology, University of Illinois at Chicago, Chicago, IL, United States of America.
University of Illinois Chicago · USJesse Brown VA Medical Center · US

Funding

Transporter Trafficking Mechanisms in Infectious DiarrheaR01DK092441 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 2011 to 2020
$3.0M
Intestinal 5-HT Transporter: A novel therapeutic target for GI disordersR01DK098170 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GILL, RAVINDER K · 2014 to 2022
$3.0M
Novel role of serotonin in AhR dependent pathways in intestineF30DK113703 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MANZELLA, CHRISTOPHER ROBERT · 2017 to 2020
$199k
BLRD VA I01 BX000152BLRD VA I01 BX002011BLRD VA I01 BX002867BLRD VA IK6 BX005243NIDDK NIH HHS F30 DK113703NIDDK NIH HHS R01 DK092441NIDDK NIH HHS R01 DK098170
6 · The paper itself

Abstract

The serotonin transporter (SERT, SLC6A4) is a Na

Indexed as

IntestineSerotoninSERTSLC6A4Untranslated regions

Identifiers

PMID34113740
PMCPMC8188842
OpenAlexW2982532477

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.