ArticleTransplantation direct2021
Cumulative Deficits Frailty Index Predicts Outcomes for Solid Organ Transplant Candidates.
Article in Transplantation direct, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Social vulnerability indices for proactively identifying at-risk individuals in healthcare: a systematic review.European journal of public health · 2025Pooled it
- Peri-transplant frailty changes impact survival in interstitial lung diseases.ERJ open research · 2026Article
- Deconditioning or biology? Triaging frailty in lung transplant candidates.ERJ open research · 2026Article
- Using kidney transplantation to explore epigenetic markers of frailty.GeroScience · 2026Article
- Article
- Frailty indices based on routinely collected data: a scoping review.The Journal of frailty & aging · 2025Article
- Relationships Between Nutrition Risk and Frailty in Candidates for Lung Transplant.Clinical transplantation · 2025Article
- The perioperative management of geriatric patients in transplantation surgery-clinical, immunological, and translational considerations.Frontiers in transplantation · 2025Review
- Putting Guidelines Into Practice: Is Frailty Measurement at the Time of Kidney Transplant Eligibility Assessment Valid, Feasible, and Acceptable to Patients?Transplantation direct · 2023Article
- Nutritional Risk of Candidates for Simultaneous Pancreatic-Kidney Transplantation-A Narrative Review.Nutrients · 2023Review
- The interplay of physical and cognitive function in rehabilitation of interstitial lung disease patients: a narrative review.Journal of thoracic disease · 2023Review
- Development of the Lung Transplant Frailty Scale (LT-FS).The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Frailty as a predictor of poor outcomes among patients awaiting liver transplant: a systematic review and meta-analysis.Gastroenterology and hepatology from bed to bench · 2023Review
- Frailty and Age-Associated Assessments Associated with Chronic Kidney Disease and Transplantation Outcomes.Journal of transplantation · 2023Review
- Updates in Kidney Transplantation From the 2022 Banff-Canadian Society of Transplantation Joint Meeting: Conference Report.Canadian journal of kidney health and disease · 2023Article
- Frailty and solid-organ transplant candidates: a scoping review.BMC geriatrics · 2022Article
- Frailty in kidney transplantation: a review on its evaluation, variation and long-term impact.Clinical kidney journal · 2022Review
- The Intersection of Aging and Lung Transplantation: its Impact on Transplant Evaluation, Outcomes, and Clinical Care.Current transplantation reports · 2022Article
- Feasibility of Virtual Assessment of Physical Frailty in Solid Organ Transplant Recipients: A Single Center, Observational Study.International journal of telerehabilitation · 2022Article
- Clinical implications of frailty in hospitalized patients with pulmonary arterial hypertension.Chronic respiratory diseaseArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite comprehensive multidisciplinary candidacy assessments to determine appropriateness for solid organ transplantation, limitations persist in identifying candidates at risk of adverse outcomes. Frailty measures may help inform candidacy evaluation. Our main objective was to create a solid organ transplant frailty index (FI), using the cumulative deficits model, from data routinely collected during candidacy assessments. Secondary objectives included creating a social vulnerability index (SVI) from assessment data and evaluating associations between the FI and assessment, waitlist, and posttransplant outcomes.
methodsIn this retrospective cohort study of solid organ transplant candidates from Toronto General Hospital, cumulative deficits FI and SVI were created from data collected during candidacy evaluations for consecutive kidney, heart, liver, and lung transplant candidates. Regression modeling measured associations between the FI and transplant listing, death or removal from the transplant waitlist, and survival after waitlist placement.
resultsFor 794 patients, 40 variable FI and 10 variable SVI were created (258 lung, 222 kidney, 201 liver, and 113 heart transplant candidates). The FI correlated with assessment outcomes; patients with medical contraindications (mean FI 0.35 ± 0.10) had higher FI scores than those listed (0.29 ± 0.09),
conclusionsA cumulative deficits FI can be derived from routine organ transplant candidacy evaluations and may identify candidates at higher risk of adverse outcomes.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.