Evidence map›Paper›PMID 34113712›Full record

ArticleTransplantation direct2021

Solid Organ Transplantation During COVID-19 Pandemic: An International Web-based Survey on Resources' Allocation.

Francesco Giovinazzo, Alfonso W Avolio, Federica Galiandro, Alessandro Vitale, Giulio V Dalla Riva, Gianni Biancofiore, Shivani Sharma, Paolo Muiesan, Salvatore Agnes, Patrizia Burra

Abstract read
In one paragraph

Article in Transplantation direct, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Francesco GiovinazzoFondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Alfonso W AvolioFondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Federica GaliandroFondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Alessandro VitaleGeneral Surgery and Liver Transplant Unit, Azienda Ospedaliera Universitaria, Padua, Italy.
Giulio V Dalla RivaSchool of Mathematics and Statistics, University of Canterbury, Canterbury, New Zealand.
Gianni BiancofioreDepartment of Anaesthesia and Intensive Care, University of Pisa, Pisa, Italy.
Shivani SharmaEquality, Diversity and Widening Participation Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.
Paolo MuiesanDepartment of Surgery, Liver Unit, University Hospital Birmingham, Birmingham, United Kingdom.
Salvatore AgnesFondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Patrizia BurraDepartment of Surgery, Oncology and Gastroenterology, Azienda Ospedaliera Universitaria, Padua, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Solid organ transplants (SOTs) are life-saving interventions, recently challenged by coronavirus disease 2019 (COVID-19). SOTs require a multistep process, which can be affected by COVID-19 at several phases.

methodsSOT-specialists, COVID-19-specialists, and medical ethicists designed an international survey according to CHERRIES guidelines. Personal opinions about continuing SOTs, safe managing of donors and recipients, as well as equity of resources' allocation were investigated. The survey was sent by e-mail. Multiple approaches were used (corresponding authors from Scopus, websites of scientific societies, COVID-19 webinars). After the descriptive analysis, univariate and multivariate ordinal regression analysis was performed.

resultsThere were 1819 complete answers from 71 countries. The response rate was 49%. Data were stratified according to region, macrospecialty, and organ of interest. Answers were analyzed using univariate-multivariate ordinal regression analysis and thematic analysis. Overall, 20% of the responders thought SOTs should not stop (continue transplant without restriction); over 70% suggested SOTs should selectively stop, and almost 10% indicated they should completely stop. Furthermore, 82% agreed to shift resources from transplant to COVID-19 temporarily. Briefly, main reason for not stopping was that if the transplant will not proceed, the organ will be wasted. Focusing on SOT from living donors, 61% stated that activity should be restricted only to "urgent" cases. At the multivariate analysis, factors identified in favor of continuing transplant were Italy, ethicist, partially disagreeing on the equity question, a high number of COVID-19-related deaths on the day of the answer, a high IHDI country. Factors predicting to stop SOTs were Europe except-Italy, public university hospital, and strongly agreeing on the equity question.

conclusionsIn conclusion, the majority of responders suggested that transplant activity should be continued through the implementation of isolation measures and the adoption of the COVID-19-free pathways. Differences between professional categories are less strong than supposed.

Identifiers

PMID34113712
PMCPMC8184017

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.