Evidence map›Paper›PMID 34113697›Full record

ArticleNeurobiology of stress2021

Early life adversity predicts brain-gut alterations associated with increased stress and mood.

Elena J L Coley, Emeran A Mayer, Vadim Osadchiy, Zixi Chen, Vishvak Subramanyam, Yurui Zhang, Elaine Y Hsiao, Kan Gao, Ravi Bhatt, Tien Dong and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elena J L ColeyDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Emeran A MayerG. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles, USA.
Vadim OsadchiyG. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles, USA.
Zixi ChenG. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles, USA.
Vishvak SubramanyamG. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles, USA.
Yurui ZhangG. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles, USA.
Elaine Y HsiaoDavid Geffen School of Medicine, University of California, Los Angeles, USA.
Kan GaoLaboratory of Gastrointestinal Microbiology, Nanjing Agricultural University, PR China.
Ravi BhattG. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles, USA.
Tien DongG. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles, USA.
Priten VoraG. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles, USA.
Bruce NaliboffG. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles, USA.
Jonathan P JacobsDavid Geffen School of Medicine, University of California, Los Angeles, USA.
Arpana GuptaG. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles, USA.

Funding

PERCEPTION AND MODULATION OF VISCERAL SENSATIONSR01DK048351 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 1996 to 2019
$8.2M
Social Isolation and Discrimination as Stressors Influencing Brain-Gut Microbiome Alterations among Filipino and Mexican AmericanR01MD015904 · NIMHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHURCH, ARPANA · 2021 to 2025
$4.1M
Role of Inflammatory Processes in Reward Network Alterations in ObesityK23DK106528 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHURCH, ARPANA · 2016 to 2020
$1.0M
Role of the Gut Microbiome in Reward Network Alterations in ObesityR03DK121025 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHURCH, ARPANA · 2020 to 2021
$234k
Functional Role of IL-6 in Fetal Brain Development and Abnormal BehaviorF31MH090749 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI HSIAO, ELAINE · 2011 to 2012
$64k
CSRD VA IK2 CX001717NIDDK NIH HHS K23 DK106528NIDDK NIH HHS R01 DK048351NIDDK NIH HHS R03 DK121025NIMHD NIH HHS R01 MD015904NIMH NIH HHS F31 MH090749
6 · The paper itself

Abstract

Alterations in the brain-gut system have been implicated in various disease states, but little is known about how early-life adversity (ELA) impacts development and adult health as mediated by brain-gut interactions. We hypothesize that ELA disrupts components of the brain-gut system, thereby increasing susceptibility to disordered mood. In a sample of 128 healthy adult participants, a history of ELA and current stress, depression, and anxiety were assessed using validated questionnaires. Fecal metabolites were measured using liquid chromatography tandem mass spectrometry-based untargeted metabolomic profiling. Functional brain connectivity was evaluated by magnetic resonance imaging. Sparse partial least squares-discriminant analysis, controlling for sex, body mass index, age, and diet was used to predict brain-gut alterations as a function of ELA. ELA was correlated with four gut-regulated metabolites within the glutamate pathway (5-oxoproline, malate, urate, and glutamate gamma methyl ester) and alterations in functional brain connectivity within primarily sensorimotor, salience, and central executive networks. Integrated analyses revealed significant associations between these metabolites, functional brain connectivity, and scores for perceived stress, anxiety, and depression. This study reveals a novel association between a history of ELA, alterations in the brain-gut axis, and increased vulnerability to negative mood and stress. Results from the study raise the hypothesis that select gut-regulated metabolites may contribute to the adverse effects of critical period stress on neural development via pathways related to glutamatergic excitotoxicity and oxidative stress.

Indexed as

Anxiety/depressionBrain functional connectivityBrain-gut microbiomeCNS, central nervous systemEarly life adversityELA, early life adversityGlutamatergic excitotoxicityPerceived stressPLS-DA, partial least squares discriminant analysisRMS, root mean squared

Identifiers

PMID34113697
PMCPMC8170500

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.