Evidence map›Paper›PMID 34113688›Full record

ArticleOpen forum infectious diseases2021

Peer Mobilization and Human Immunodeficiency Virus (HIV) Partner Notification Services Among Gay, Bisexual, and Other Men Who Have Sex With Men and Transgender Women in Coastal Kenya Identified a High Number of Undiagnosed HIV Infections.

Maartje Dijkstra, Khamisi Mohamed, Alex Kigoro, Teresia Mumba, Shally Mahmoud, Abdalla Wesonga, Nana Mukuria, Tony Oduor, Evans Gichuru, Maarten F Schim van der Loeff and 4 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Self-Testing as a Hope to Reduce HIV in Transgender Women-Literature Review.International journal of environmental research and public health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 4 countries.

Maartje DijkstraDepartment of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0003-2561-7659
Khamisi MohamedKenya Medical Research Institute-Wellcome Trust Research Program, Kilifi, Kenya.
Alex KigoroKenya Medical Research Institute-Wellcome Trust Research Program, Kilifi, Kenya.
Teresia MumbaKenya Medical Research Institute-Wellcome Trust Research Program, Kilifi, Kenya.
Shally MahmoudKenya Medical Research Institute-Wellcome Trust Research Program, Kilifi, Kenya.
Abdalla WesongaKenya Medical Research Institute-Wellcome Trust Research Program, Kilifi, Kenya.
Nana MukuriaKenya Medical Research Institute-Wellcome Trust Research Program, Kilifi, Kenya.
Tony OduorKenya Medical Research Institute-Wellcome Trust Research Program, Kilifi, Kenya.
Evans GichuruKenya Medical Research Institute-Wellcome Trust Research Program, Kilifi, Kenya.
Maarten F Schim van der LoeffDepartment of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, The Netherlands.
Shaun PalmerKenya Medical Research Institute-Wellcome Trust Research Program, Kilifi, Kenya.
Susan M GrahamKenya Medical Research Institute-Wellcome Trust Research Program, Kilifi, Kenya.
Elise M van der ElstKenya Medical Research Institute-Wellcome Trust Research Program, Kilifi, Kenya.
Eduard J SandersKenya Medical Research Institute-Wellcome Trust Research Program, Kilifi, Kenya.
Kenya Medical Research Institute · KEAmsterdam UMC Location University of Amsterdam · NLUniversity of Washington · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Impact of a novel screening program to detect acute and prevalent HIV infection and reduce HIV transmissionR01AI124968 · NIAID · UNIVERSITY OF WASHINGTON · PI GRAHAM, SUSAN MARIE, SANDERS, EDUARD · 2016 to 2019
$2.3M
NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI124968Wellcome Trust 107752Wellcome Trust 203077
6 · The paper itself

Abstract

backgroundHuman immunodeficiency virus (HIV) partner notification services (HPN), peer mobilization with HIV self-testing, and acute and early HIV infection (AEHI) screening among gay, bisexual, and other men who have sex with men (GBMSM) and transgender women (TGW) were assessed for acceptability, feasibility, and linkage to antiretroviral therapy (ART) and preexposure prophylaxis (PrEP) services.

methodsBetween April and August 2019, peer mobilizers mobilized clients by offering HIV oral self-tests and immediate clinic referral for clients with AEHI symptoms. Mobilized participants received clinic-based rapid antibody testing and point-of-care HIV RNA testing. Newly diagnosed participants including those derived from HIV testing services were offered immediate ART and HPN. Partners were recruited through HPN.

resultsOf 772 mobilized clients, 452 (58.5%) enrolled in the study as mobilized participants. Of these, 16 (3.5%) were HIV newly diagnosed, including 2 (0.4%) with AEHI. All but 2 (14/16 [87.5%]) initiated ART. Thirty-five GBMSM and TGW were offered HPN and 27 (77.1%) accepted it. Provider referral identified a higher proportion of partners tested (39/64 [60.9%] vs 5/14 [35.7%]) and partners with HIV (27/39 [69.2%] vs 2/5 [40.0%]) than index referral. Of 44 enrolled partners, 10 (22.7%) were newly diagnosed, including 3 (6.8%) with AEHI. All 10 (100%) initiated ART. PrEP was initiated among 24.0% (103/429) mobilized participants and 28.6% (4/14) partners without HIV.

conclusionsHPN, combined with a peer mobilization-led self-testing strategy and AEHI screening for GBMSM and TGW, appears to be acceptable and feasible. These strategies, especially HPN provider referral, effectively identified undiagnosed HIV infections and linked individuals to ART and PrEP services.

Indexed as

acute HIV infectionpartner notificationself-testingsexual and gender minoritiessub-Saharan Africa

Identifiers

PMID34113688
PMCPMC8186249
OpenAlexW3158357424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.